Relationship Between Ageing And The Comorbid Clinical Classifications Of ASCVD

Objective: To explore the relationship between the increasement of age and the clinical classifications of atherosclerotic cardiovascular disease(ASCVD),and the relationship between age and other cardiovascular risk factors.Methods: A total of 1014 patients admitted in our hospital from 2016-07 to 2017-07 were enrolled.According to the clinic classification of ASCVD,the patients were divided into 3 groups: Group A,the patients without ASCVD,including 82 female and 48 male,n=130;Group B,the patients with one of the following disease: stroke,coronary artery disease(CAD)or peripheral artery disease(PAD),including 168 female and 166 male,n=334;Group C,the patients with ischemia stroke+CAD,stroke+PAD,CAD+PAD or stroke+CAD+PAD,including 219 female and 331 male,n=550.Firstly,the baseline of clinical data among 3 groups were compared.Then,the risk factors for multiple clinic classifications of ASCVD were explored by Binary Logistic regression analysis.Besides,the correlation between age and other risk factors were analyzed.Results: Patients in group C were older than those in group B,(76.49±8.07)years vs(70.20±9.02)years,P<0.01.Multivariate logistic regression analysis of cardiovascular risk factors suggested that ageing(OR=1.059,95%CI:1.038~1.080),cIMT(OR=15.177,95%CI:4.369~52.723),smoking(OR=2.472,95%CI:1.709~3.576),diabetes(OR=1.890,95%CI:1.273~2.806),Cr(OR=1.028,95%CI:1.019~1.037),and PP(OR=1.029,95%CI:1.011~1.048)were independently associated with multiple clinical classifications of ASCVD.Bivariate Spearman correlation analysis and partial correlation analysis showed that ageing was significantly positively correlated with cIMT,Cr,and PP in the above risk factors.(P<0.01).Conclusions: Age and cIMT,Cr and PP have synergistic effects on the development of multiple clinical classifications of ASCVD.As the risk of comorbid clinical classifications of ASCVD was increasing by age increasing,it is necessary to start monitoring the relevant risk indicators as early as possible.