Study On The Correlation Between Serum Neuroglobin And Progressive Stroke

ObjectiveIschemic stroke accounts for 60%-80% of all strokes,and has shown a gradual upward trend in recent years.About 40% of patients with ischemic stroke can progress in early stroke,called progressive cerebral infarction(Stroke in Progression,SIP),a type of ischemic stroke with poor efficacy,clearly increases the mortality and disability rate of patients,and becomes the first factor affecting the life expectancy of Chinese people.Therefore,it is of great clinical significance to clarify the possible mechanisms of its occurrence and development and related risk factors.Neuroglobin(NGB),as a new type of highly efficient oxygen-carrying globulin,has a high affinity with oxygen and plays an important role in oxygen metabolism and oxygen utilization of tissue cells.Oxygen tolerance,scavenging free radicals,anti-apoptosis,etc.exert their neuroprotective effects.Animal experiments found that intracranial ischemia,hypoxia,oxidative stress and toxic damage,serum NGB expression increased,and may be closely related to the severity of disease and disease progression of ischemic stroke,but the relevant clinical studies are rare,so clear ischemia The changes and evolution of serum NGB levels in patients with stroke,and whether NGB can be used as a specific biomarker for the occurrence,development and prognosis of SIP has certain exploration value.MethodsThis study included 60 patients with acute cerebral infarction(ACI)who were admitted to the Department of Neurology,the First Affiliated Hospital of Xi’an Medical College from April 2017 to February 2018,including 40 non-SIP groups(observation group).There were 20 patients in the SIP group(study group)and 40 healthy controls with age,gender,and education level.Collect and organize general information and clinical data of all subjects,using the National Institutes of Health neurological deficit score(NHISS),Scandinavian Stroke Study(SSS),and improvement The Rankin Scale(mRS)was used to assess the severity,progression and prognosis of the observation group and the study group.The ACI patients were admitted to the hospital by Enzyme Linked Immunosorbent Assay(ELISA).),3 days,7 days of serum samples and healthy subjects in the morning fasting serum samples,using t test,analysis of variance(ANOVA),nonparametric test,Pearson correlation analysis,partial correlation,ROC curve,two classification Logistic Statistical analysis was performed by regression analysis and thelike.Results1.The serum NGB level of ACI patients was significantly higher than that of healthy controls at each time point(P<0.01).The serum NGB levels of SIP patients at different time points were significantly higher than those of non-SIP patients(P<0.01).2.Serum NGB in ACI patients gradually increased at each time point of detection,7d>3d>1d;3.The more severe the neurological deficit of SIP patients,the more serious the progression of the disease,the higher the serum NGB expression level,the worse the early prognosis(P<0.01);4.The degree of neurological deficit(SIPS r=0.81,P<0.01)and the degree of disease progression(SSS r=0.81,P<0.01)in SIP patients were positively correlated with serum NGB levels);5.The 1st serum NGB level of ACI patients >30.76ng/ml is the optimal threshold for predicting SIP(AUC=0.748±0.064,P<0.01,sensitivity: 75.0%,specificity: 67.5%);6.Binary logistic regression analysis: serum NGB level,LDL,FBI are independent risk factors for SIP.Conclusions1.The level of serum NGB is Positive correlated with the degree of neurological impairment of SIP patients,which may be a judge indicator of the severity of SIP;2.Serum NGB level is Positive correlated with the progress of SIP disease,which may be a biomarker to evaluate the risk of SIP occurrence;3.Serum NGB level,LDL,and FBI are independent risk factors for SIP.