Related Research About TCM Syndromes Of Essential Hypertension In Patient With AIP, IMT And AASI

ObjectiveTo study the relevance of primary Essential hypertension(EH)patients with differe nt TCM syndrome types and Atherogenic index of plasma(AIP),Carotid intimal media l thickness(IMT),Ambulatory arterial stiffness index(AASI).It is expected to provide r eference and basis for clinicians to use syndrome differentiation and comprehensive tra ditional Chinese and western medicine to treat hypertension and delay the process of Atherosclerosis(AS).MethodsRetrospectively collected from January to December 2018 in the Second People's Hospital of Fujian Province,120 cases of patients with EH,making unified questionna ires to collect medical records information,including information about syndrome,the related medical history,auxiliary examination,primary clinical diagnosis,sydrome diffe rentiation of TCM is divided into essence of hyperactivity of liver yang syndrome,qi and blood deficiency syndrome,phlegm and blood stasis symdrome,kidney essence defi ciency syndrome.Statistical methods were used to study the correlation between AIP,I MT,AASI and TCM syndromes,hypertension levels in patients with hypertension,and to explore the influencing factors of AIP,IMT,AASI and their correlation.Result1.The higher the blood pressure level was,the older the EH patients were,and the longer the course of disease was(? <0.05).With the increase of blood pressure le vel,IMT,AIP and AASI all increased gradually(? <0.05).AIP,IMT and AASI in E H patients were positively correlated with age,blood pressure level and disease course(? <0.05),and AIP,IMT and AASI were positively correlated with each other(? <0.05).2.Syndrome type of TCM composition ratio distribution of 120 cases of EH pati ents: phlegm and blood stasis syndrome(42.50%)>qi and blood deficiency syndrome(25.83%)>hyperactivity of liver yang syndrome(16.67%)>kidney essence deficiency syn drome(15.00%).3.There was no statistical difference in the gender composition of TCM syndrom es in EH patients(? >0.05).In terms of age distribution,except that there was no sta tistical difference between qi and blood deficiency syndrome and phlegm and blood st asis syndrome(? >0.05),there were statistical differences between the other groups(?<0.05),The hyperactivity of liver yang syndrome is the youngest,and the kidney ess ence deficiency syndrome is the oldest.In terms of age stratified distribution,the hyper activity of liver yang syndrome is mainly distributed between 50 and 59 years old,th e qi and blood deficiency syndrome is mainly distributed between 60 and 69 years ol d,the phlegm and blood stasis symdrome is mainly distributed between 50 and 69 y ears old,and the kidney essence deficiency syndrome is mainly distributed between 70 and 80 years old.4.In terms of blood pressure scale,grade 1 and grade 2 hypertension were the m ain syndromes of hyperactivity of liver yang syndrome;Grade 2 and grade 3 hypertension were the main syndromes of qi and blood deficiency syndrome and kidney essen ce deficiency syndrome.The syndrome of phlegm and blood stasis symdrome was dist ributed in hypertension at all levels.In the course of disease,kidney essence deficiency syndrome>qi and blood deficiency syndrome>phlegm and blood stasis symdrome>hyp eractivity of liver yang syndrome(? <0.05).5.Body mass index(BMI)comparison: phlegm and blood stasis symdrome>qi an d blood deficiency syndrome/kidney essence deficiency syndrome(? <0.05).6.Triglycerides(TG)comparison:phlegm and blood stasis symdrome>hyperactivity of liver yang syndrome/qi and blood deficiency syndrome;Comparison of Cholesterol(TC): phlegm and blood stasis symdrome>qi and blood deficiency syndrome/kidney es sence deficiency syndrome,hyperactivity of liver yang syndrome>qi and blood deficien cy syndrome;Comparison of Low density lipoprotein cholesterol(LDL-C): hyperactivity of liver yang syndrome<qi and blood deficiency syndrome<phlegm and blood stasis symdrome/kidney essence deficiency syndrome;Comparison of High density lipoprot ein cholesterol(HDL-C):phlegm and blood stasis symdrome<hyperactivity of liver yan g syndrome/qi and blood deficiency syndrome,kidney essence deficiency syndrome<h yperactivity of liver yang syndrome/qi and blood deficiency syndrome,The above diffe rences were statistically significant(? <0.05).comparison of AIP: phlegm and blood st asis symdrome>hyperactivity of liver yang syndrome/qi and blood deficiency syndrom e(P<0.05),kidney essence deficiency syndrome> hyperactivity of liver yang syndrome/qi and blood deficiency syndrome(? <0.05).7.Compared of IMT,hyperactivity of liver yang syndrome<qi and blood deficienc y syndrome<phlegm and blood stasis symdrome/kidney essence deficiency syndrome(? <0.05).In terms of age distribution showed that among patients aged 50-59 years,hyperactivity of liver yang syndrome/qi and blood deficiency syndrome<phlegm and blood stasis symdrome(? <0.05),while among patients aged 60-69 years,qi and bloo d deficiency syndrome<phlegm and blood stasis symdrome(? <0.05).8.AASI comparison results found: hyperactivity of liver yang syndrome<phlegm and blood stasis symdrome/kidney essence deficiency syndrome(? <0.05),qi and bloo d deficiency syndrome<phlegm and blood stasis symdrome(? <0.05).9.AIP,IMT and AASI indexes of phlegm and blood stasis symdrome had the hi ghest incidence of abnormalities(? <0.05).Conclusion1.With the increase of EH patients' age,hypertension level and disease course,AIP,IMT and AASI all gradually increased,and the degree of AS gradually increased.AI P,IMT and AASI are consistent in evaluating the degree of AS,which can be used f or objective reference indexes for TCM syndrome differentiation of hypertension patien ts,and assist in judging the degree of arteriosclerosis of patients.2.The proportion of TCM syndrome in EH is from large to small,followed by phlegm and blood stasis syndrome>qi and blood deficiency syndrome>hyperactivity o f liver yang syndrome>kidney essence deficiency syndrome.3.With the increase of age,the increase of blood pressure level and the prolongi ng of the course of disease in EH patients,the syndromes of TCM generally present the disease evolution from excess-syndrome to deficiency-syndrome.The BMI of exces s-syndrome was larger than that of deficiency-syndrome.4.The degree of dyslipidemia in the syndrome of phlegm and blood stasis symdr ome is more severeand,AIP and AASI are both higher than those of hyperactivity of liver yang syndrome and qi and blood deficiency syndrome.The AS degree of phleg m and blood stasis symdrome and kidney essence deficiency syndrome is more serious than hyperactivity of liver yang syndrome and qi and blood deficiency syndrome,wh ich can be used as one of the objective bases of syndrome differentiation.5.The IMT of phlegm and blood stasis symdrome and kidney essence deficiency syndrome was higher than that of hyperactivity of liver yang syndrome and qi and b lood deficiency syndrome.IMT can be used as an objective reference index for distin ction of phlegm and blood stasis symdrome in patients aged 50-69 years.6.AIP,IMT and AASI indexes of phlegm and blood stasis symdrome have the h ighest incidence of abnormalities,which can be used as an objective reference index f or syndrome differentiation and monitoring AS changes.