| Objective 1.To analyze the serum 25(OH)D level and its influencing factors in infertile men.2.To observe the effect of vitamin D intervention on semen quality in infertile men.3.To analyze low serum 25(OH)D and reproductive hormone in infertile men.4.To analysis of the correlation between low serum 25(OH)D and depression in infertile men.Methods A total of 98 infertile male patients who were admitted to the Reproductive Medicine Center of Ningxia Medical University General Hospital from July 2018 to Novemberr 2018 and tested for serum 25(OH)D levels were collected.The serum 25(OH)of infertile men and its influencing factors were analyzed.A group of oligozoospermia and asthenospermia infertile men with serum 25(OH)D<30ng/ml who were randomly divided into study group and control group,with 25 case in each group.The control group was given sun intervention and oral treatment of compound Xuanju and Xuefu Zhuyu capsule.The study group was additionally injected vitamin D2 and given calcium carbonate D3 tablets on the basic of treatment in the control group.Patients were scored by the Self-rating Depression Scale(SDS)and 34 patients were tested for reproductive hormone.Semen parameters was reexamined after 12 weeks.To observe the pregnancy of the woman and the adverse reactions during the treatment.Outcome 1.Vitamin D was normal in 20.41% of 98 infertile men.Vitamin D insufficient accounted for 45.92%.Vitamin D deficiency accounted for 31.63%.2.04% of the patients had severe vitamin D deficiency.There was no significant difference in vitamin D levels between infertile men of different BMI,ages and professions(P>0.05).Serum 25(OH)D levels in infertile men were negatively correlated with BMI(r=-0.333,P<0.05)and were not associated with age(r=-0.042,P>0.05).2.(1)There was no significant difference in age,BMI,years of sterility,type of infertility and causes of infertility between the two groups(P>0.05).(2)There was no significant difference in sperm concentration,sperm survival rate,percentage of progressive motile sperm and serum 25(OH)D level between the two groups before treatment(P>0.05).(3)After treatment,the sperm concentration increased from(68.58±32.82)×106/ml to(90.98 ±48.19)×106/ml and the percentage of progressive motile sperm increased from(17.62 ±9.19)% to(25.84±17.46)%.The differences were statistically significant(P<0.05).The survival rate of spermatozoa increased from(36.25±21.02)% to(43.75±20.07)%,but there was no significant difference(P>0.05).In the control group,the percentage of progressive motile sperm increased from(15.84±10.53)% to(25.94±13.55)%.The difference was statistically significant(P<0.05).The sperm concentration increased from(75.54±44.24)×106/ml to(87.38 ±33.59)×106/ml and the sperm survival rate increased from(36.67±17.37)% to(42.07 ±15.92)%.But there was no significant difference(P>0.05).There was no significant difference in the increased percentage of progressive motile sperm after treatment between the two groups(P>0.05).No adverse reactions were observed in all patients.(4).Two cases were spontaneous conception pregnancy in each group.In the study group,there were five cases pregnancy through IVF-ET.The control group had three cases pregnancy through IVF-ET.There was no significant difference in clinical pregnancy rate between the two groups(P>0.05).3.The correlation coefficients between low serum25(OH)D and FSH,LH,T,E2,PRL,in infertile men were-0.097?-0.022?0.127?-0.116?-0.230,P>0.05,respectively.There's no correlation between them(P>0.05).4.There was no correlation between low serum 25(OH)D and depression in infertile men(r =-0.032,P>0.05).Conclusion 1.Infertile male are prevalent in vitamin D deficiency.Vitamin D is one of the important factors affecting vitamin D level.2.Vitamin D supplementation can significantly increase the sperm concentration of infertile men,but can not significantly improve the pregnancy rate of the woman.3.Low serum 25(OH)D has no correlation with reproductive hormonesin infertile men.4.Low serum 25(OH)D was not associated with depressionin infertile men. |
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