The Relationship Between The Expression Of Ki67,P53 And CEA With Clinicopathological Features Of Rectal Adenocarcinoma And Its Significance

Objective: To analyze the correlation between the expression of Ki67、P53 and serum CEA with the clinicopathological features in rectal adenocarcinoma,and analyze its clinical value.Methods: Epidemiological data(age,gender,smoking history,and alcohol intake)and clinicopathological parameters(invasive depth,lymphatic metastasis,differentiation,TNM stage)of 354 patients with rectal adenocarcinoma who undergoing radical surgical resection in The First Hospital of China Medical University from January 2015 to October 2015 were collected.The expression of Ki67 and P53 and serum value CEA were detected.Statistical analysis was performed.Results: The positive rates of Ki67 and P53 were higher in the patients aged ≥65 years,with lymph node metastasis,lower differentiation,and later in TNM stage(P<0.05).CEA levels were also higher(P<0.05).There was a statistically significant difference in the CEA levels in patients with serosa invasive(+)(P<0.001);The positive rates of Ki67 and P53 were no statistical difference in gender differences,whether they smoked,whether they drank alcohol,and whether serosa invasive positive.There was a positive correlation between Ki67 positive expression rate and CEA level(r=0.106;p<0.05),but there was no significant correlation between the positive expression rate of P53 and CEA(P>0.05).Conclusion: There is a close relationship between the positive expression rate of Ki67 and P53 in patients with rectal adenocarcinoma with age,lymph node metastasis,differentiation and TNM staging.The positive expression rate of Ki67 is positively correlated with the level of CEA and can be used to indicate the prognosis of patients and guide clinical treatment.