Analysis Of The Correlation Between Plasma Catestatin,Pentraxin 3 Levels And Acute Coronary Syndrome,Vulnerable Plaque

Objectives:To explore the predictive factors of coronary atherosclerotic plaque stability,we investigate the role of plasma catestatin and Pentraxin 3 levels in the clinical classification of coronary heart disease,degree of coronary artery stenosis,and the character of coronary atherosclerotic plaque which determined by Optical Coherence Tomography.According to the results,we analyzed whether plasma catestatin and Pentraxin 3 levels could be used to measure the stability of coronary atherosclerotic plaque.Methods:From October 2014 to March 2018,a total of 166 patients with chest pain,in Department of Cardiology of the First Affiliated Hospital of Kunming Medical University,whose willing to receive Coronary Angiography examination were recruited in this study.Firstly,the information of age,sex,lipid status,hypertension history,diabetes history,smoking history and other diseases were collected.Secondly,the elbow venous blood was extracted from research target,and the plasma were be stored in-80OC refrigerator.Enzyme-linked Immuno Sorbent Assay was used to detect the level of CST and PTX3 in plasma.Third,all the subjects were examined by CAG.According to clinical manifestations and CAG results,the subjects were divided into non-coronary heart disease group(control group),Stable Angina Pectoris group,and Acute Coronary Syndrorue group(Acute Coronary Syndrome group can be further divided into Unstable Angina Pectoris subgroup,Non-ST Elevation Myocardial Infarction subgroup and ST Elevation Myocardial Infarction subgroup).The subjects were Gensini scored according to the results of CAG.Finally,non-myocardial infarction patients who were confirmed by coronary angiography examination and willing to receive OCT examination were divided into Stable Plaque group and Unstable Plaque group according to the results of OCT examination.The data was analyzed by SPSS 19.0 software.P<0.05 is statistically significant differences.Results:1?The rate of hypertension,diabetes mellitus,smoking history and plasma LDL in SAP and ACS groups were higher than those in control group(P<0.05),and the male ratio in ACS group was higher than that in control group and SAP group(P<0.05).2?The plasma level of CST in ACS group were higher than those in SAP group and control group(P<0.01);the plasma level of PTX3 in SAP group and ACS group were higher than those in control group(P<0.01);the plasma level of CST in STEMI group and NSTEMI group were lower than those in SAP group(P<0.05);the plasma level of PTX3 in STEMI group were higher than those in SAP group(P<0.05);the plasma level of CST and PTX3 in UP group were higher than those in SP group(P<0.01).3?The number of coronary Gensini scores in ACS group were higher than those in SAP group(P<0.05);the Gensini scores in SAP group,UAP group,STEMI group and NSTEMI group increased gradually(P<0.05).4?The plasma level of CST were moderately correlated with plasma level of PTX3(r=0.748),moderately correlated with Gensini score(r=0.737),and the correlation was statistically significant(P<0.01).The plasma levels PTX3 were highly correlated with Gensini score(r=0.817),and the correlation was statistically significant(P<0.01).5?The thickness of fibrous cap,the angle of lipid pool,the ratio of neovascularization,the ratio of thrombosis and macrophage accumulation in UP group were higher than those in SP group(P<0.05).There was no significant difference indegree of stenosis between SP group and UP group(P>0.05).6?Regarding plaque stability as dependent variable and plasma level of CST,PTX3,LDL,HDL,TG,TC,and age,sex,hypertension,diabetes and smoking as independent variables,the regression coefficient of CST was>0,OR value was>1,which indicat that CST is an independent risk factor to affect plaque stability.Conclusion(s):1?The plasma level of CST and PTX3 were positively correlated with the severity of coronary stenosis.2?The consistence of CST and PTX3 of plasma is related to the occurrence of acute coronary syndrome.3?The consistence of CST in plasma of the patients with vnlnerable plaque is high.According to the level of CST in plasma,cardiac function,hypertension and arrhythmia in patients,the stability of coronary plaque can be roughly reflected.