| Objectives:To evaluate the clinical efficacy and safety of long pulsed 1064nm Nd:YAG laser for the treatment of female melasma by split-face study.Methods:Twenty-four female melasma subjects with symmetrical facial lessions were enrolled,and their right side faces were treated with long pulsed 1064nm Nd:YAG laser for 5 sessions.All patients were given VISIA,CK and RCM examinations before each treatment and 4 and 8 weeks after the final treatment.The melasma area and severity index(MASI)was measured at the same time.The above measurements were compared between the treatment side and the the control side at the same time point,and compared between different time points on the treatment side or the control side.The occurrence of related abverse reactions were recorded.Results:To the MASI scores,RCM scores,VISIA values and the melanin and hemoglobin of CK,There were no statistical differences(P>0.05)between the treatment side and the control side before the first treatment;The scores of treatment side were lower(P<0.05)than the control side 4 weeks weeks after the final treatment;compared with the scores before the first treatment,those 4 weeks after the final treatmen decreased(p<0.05)on the treatment side;On the control side,there were no statistical differences(P>0.05)between the scores before the first treatment and 4 weeks after the final treatmen.To the value of the water content,TEWL and the sebum content,there were no statistical differences(P>0.05)between the treatment side and the control side,between 4 weeks after the the final treatmen and before the first treatment.All types of melasma(Fitzpatrick skin types or Wood’s light and glass compression types)displayed no statistical differences(P>0.05)in treatment effection and recurrence rate.No significant abverse reactions occurred in all 24 patients.Conclusion:Long pulsed 1064nm Nd:YAG laser for the treatment of female melasma is safe and effective,and it is worthy of clinical application. |
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