Venous Thromboembolism In Patients With Esophageal Cancer After Neoadjuvant Chemotherapy:Systematic Review And Meta-analysis

Objective:Venous Thromboembolism(VTE)is a common complication after neoadjuvant chemotherapy in patients with malignant tumors.The risk of VTE in patients with esophageal cancer after neoadjuvant chemotherapy remains unclear.This paper studies the incidence of VTE in patients with esophageal cancer after neoadjuvant chemotherapy through systematic reviews and meta-analysis.Methods:Through PubMed,Web of science,Ovid,China Knowledge Network,Wanfang database,and Weipu electronic database,a systematic literature search was performed according to keywords.The two review researchers independently screened the title and abstract,and extracted the data to standardization On the table,the effect of neoadjuvant chemotherapy on the occurrence of venous thromboembolism in patients with esophageal cancer was explained through systematic reviews and Meta analysis.Results:Through literature search and screening,6 retrospective studies were finally included in the qualified literature,a total of 2270 patients(range 110 to 708 cases)were included.Through the QUIPS bias risk assessment,the overall quality of the research is high.Of the 2270 esophageal cancer patients undergoing neoadjuvant chemotherapy,191 patients were diagnosed with at least one type of VTE during neoadjuvant chemotherapy.When the heterogeneity between the studies was low,the incidence of VTE after the combined effect size was 7%(95%CI,6%to 8%),the heterogeneity is due to chance.Two studies have reported VTE with clinical symptoms,with an incidence of 22%and 41%,respectively.The proportion of patients with PE is between 37%and 78%.Conclusion:Through systematic reviews and meta-analysis,it is found that the incidence of VTE is relatively high in patients with esophageal cancer after neoadjuvant chemotherapy.There is heterogeneity between studies among several studies.To effectively prevent the occurrence of VTE,it is worth looking forward to Further evaluation in sexual studies.Patients with esophageal malignant tumors have a higher risk of developing VTE during neoadjuvant chemotherapy,and need to use mechanical or medication to effectively predict pulse thrombosis during neoadjuvant chemotherapy.