Correlation Between Serum ALT,TG,LDL-C Levels And Colorectal Adenoma With Non-alcoholic Fatty Liver Disease:A Case-control Study

Objective:To investigate the clinical features of Non-alcoholic Fatty Liver Di-sease complicated with Uygur Colorectal adenoma in the Xinjiang Uygur Autonom-ous Region.Methods:The clinical data of 294 Uygur patients with colorectal ade-noma(CRA)admitted from January 2013 to March 2018 in the Second Affiliated Hospital of Xinjiang Medical University were retrospectively analyzed.According t-o the diagnosis of abdominal ultrasound,the patients were divided into the observ-ation group(110 cases with NAFLD)and the control group(184 cases without N-AFLD),compared two groups with the effects on blood lipids,blood biochemistry,liver and kidney function.Results:Age,BMI,waist-to-hip ratio(WHR)and HbA1c,FPG,UA,ALT,GGT,TG,TC,LDL-C of the observation group were signific-antly higher than those of the control group,while the level of AST was significa-ntly lower than that of the control group.The difference between the two groups was statistically significant(t=5.569、8.139、3.592、3.514、15.703、15.113、8.092、10.834、7.719、11.481、7.561,P<0.05);The proportion of smoking history in the observation group was significantly higher than that in the control group(?~2=14.060,P<0.05);Logistic regression analysis showed that age,serum ALT,TG an-d LDL-C levels and smoking history were closely related to CRA with NAFLD.T he ratios(95%CI)were 1.301(1.065-1.589)、1.383(1.059-1.805)、1.335(1.091-1.634)、1.358(1.125-1.639)、1.423(1.105-1.833).Conclusion:Elevated serum ALT,TG and LDL-C levels and smoking history were risk factors for CRA patien-ts with NAFLD.Ages above 60 years old are the high incidence age group.