The Correlation Analysis Of TCM Syndrome Elements,Risk Classification Of Carotid Plaque And Recurrence Of Ischemic Stroke

Objective:The purpose of this study was to analyze the correlation between TCM syndrome factors,carotid plaque risk classification and recurrence of ischemic stroke and provide the clinical research basis for the prevention and treatment of ischemic stroke recurrence by the combination of traditional Chinese and western medicine relying on 2015special research project of TCM and hospital information system of encephalopathy department of Affiliated Hospital of Changchun University of Traditional Chinese Medicine.Methods:Case control study was used in this study.According to the inclusion criteria,128 patients with and without recurrence of ischemic stroke in one year were selected,including 64 in the recurrence group and 64 in the non recurrence group.According to the standard of syndrome differentiation and diagnosis of Apoplexy(Trial),the TCM symptoms and signs of the two groups were extracted as the elements of TCM syndromes.The color Doppler ultrasound of carotid artery in the two groups was analyzed and the risk of carotid plaque was graded.Finally,statistical analysis(P<0.05)was carried out to explore the correlation between TCM syndrome elements,carotid plaque risk grading and the recurrence of ischemic stroke within one year.Results:The total proportion of TCM syndrome elements in all patients with ischemic stroke was in the order of phlegm>blood stasis>wind>fire>qi deficiency>yin deficiency,the proportion of TCM syndrome elements in non recurrent patients was in the order of wind>fire>phlegm=blood stasis>yin deficiency>qi deficiency,the proportion of TCM syndrome elements in recurrent patients was in the order of phlegm>blood stasis>wind>qi deficiency>fire>yin deficiency.Simply from the proportion of TCM syndrome elements,phlegm,blood stasis,wind and fire have a greater impact on the population of ischemic stroke,wind and fire are the main non recurrent patients,while most of the recurrent patients are phlegm and blood stasis.According to Pearson-χ~2 test,the composition ratio of TCM syndrome elements(phlegm,blood stasis,qi deficiency)in the recurrence group of ischemic stroke was higher than that in the non recurrence group(P<0.05);the composition ratio of TCM syndrome elements(fire)in the non recurrence group was higher than that in the recurrence group(P<0.05);the composition ratio of two composite syndrome elements(phlegm and blood stasis)in the recurrence group was higher than that in the non recurrence group(P<0.05).According to Pearson-χ~2test,the proportion of carotid plaque high risk group in patients with recurrent ischemic stroke was higher than that in patients without recurrence(P<0.05).According to Pearson-χ~2test,the proportion of TCM syndrome elements(wind)in moderate risk group of carotid plaque in non recurrent ischemic stroke patients was higher than that in high risk group(P<0.05);the proportion of TCM syndrome elements(phlegm)in high risk group of carotid plaque in non recurrent ischemic stroke patients was higher than that in moderate risk group(P<0.05).According to Pearson-χ~2 test,the composition ratio of TCM syndrome elements(wind)in the low risk group and the medium risk group was higher than that in the high risk group(P<0.05),the composition ratio of TCM syndrome elements(phlegm and blood stasis)in the high risk group was higher than that in the medium risk group(P<0.05).Conclusion:TCM syndrome factors and the risk degree of carotid plaque are the important factors affecting the recurrence of ischemic stroke.Phlegm,blood stasis and qi deficiency are the main TCM syndrome factors of patients with recurrence of ischemic stroke within one year.High risk carotid plaque is one of the risk factors of recurrence of ischemic stroke within one year.Meanwhile,the phlegm and blood stasis syndrome factors are closely related to the high risk of carotid plaque.Thus,active control of phlegm,blood stasis,qi deficiency syndrome factors,reducing the risk of carotid plaque and other controllable factors may be important measures to reduce the recurrence of ischemic stroke.