| Objective:In order to demonstrate from a scientific perspective,objectively evaluate the efficacy and medication safety of professor Shan Zhaowei’s empirical prescription chaishenjieyu decoction,improve and supplement the existing diagnosis and treatment programs,inherit and carry forward the experience of famous doctor of traditional chinese medicine,so as to make the traditional Chinese medicine better serve the clinic.Therefore,the clinical efficacy of chaishen jieyu decoction in the treatment of IBS-D(syndrome of liver stagnation and spleen deficiency)and the western medicine pivimium bromide in the control group was observed.Methods:The 60 subjects included in the experiment were randomly divided into a treatment group of 30 cases(with chaishen Jieyu Decoction plus and minus)and a control group of 30 cases(with pivermonium bromide 50mg po tid)for a 4 weeks treatment,Patients were followed up on the first day of diagnosis,the last day of the fourth week of treatment,and the last day of the month of discontinuation(±7 days),the symptom scores,anxiety levels,IBS-SSS disease severity score and IBS-QOL quality of life scores of the two groups were compared to comprehensively,objectively and scientifically evaluate the therapeutic effect,safety and maintenance of symptom improvement of the traditional chinese medicine chaishen jieyu decoction in patients with IBS-D(syndrome of liver stagnation and spleen deficiency).Results:1.Comparison of total score of TCM symptoms:Total score of TCM symptoms of the two groups were better improved after treatment and during follow-up(P<0.01);The curative effect of chaishen jieyu decoction was better than that of pivemoniuz bromide(P<0.01).2.Comparison of single points of TCM symptoms:After treatment and during follow-up,both groups could improve the single symptom of traditional Chinese medicine symptoms well(P<0.01).The effect of chaishen jieyu decoction was better than that of pivemonium bromide in the symptoms of stool frequency,stool properties,abdominal pain or abdominal discomfort,impatience and irritability,and the symptoms of fullness in two sides(P<0.05),and it had better long-term efficacy in the symptoms of stool frequency,stool properties,abdominal pain or abdominal discomfort,and the symptoms of impatience and irritability(P<0.05).3.Comparison of anxiety level:Chaishen jieyu decoction could significantly improve the anxiety level of patients(P<0.01),the effect of pivemonium bromide tablets was not obvious(P>0.05),and the effect of chaishen jieyu decoction was better than that of pivemonium bromide tablets.During follow-up,neither group had a significant effect(P>0.05).4.Comparison of total effective rate:After treatment,the total effective rate of chaishen jieyu decoction was 93.33%,and that of pivemonium bromide was 63.33%.During follow-up,the total effective rate of chaishen jieyu decoction was 83.33%,and the total effective rate of pivemonium bromide was 46.67%.Chaishen jieyu decoction was better than pivemonium bromide,which could better maintain the therapeutic effect(P<0.05).5.Comparison of IBS-SSS scale scores:After treatment and during follow-up,both groups could reduce the severity of IBS disease(P<0.01),and the effect of chaishen jieyu decoction after treatment and during follow-up was better than that of pivepronium bromide(P<0.05).6.Comparison of IBS-QOL quality of life scores:After treatment and during follow-up,the quality of life of IBS-D patients was improved in both groups(P<0.01).The curative effect of chaishen jieyu decoction after treatment was not better than that of pivionium bromide(P>0.05),but the follow-up effect was better than that of pivionium bromide(P<0.05).7.IBS-QOL score points of two groups of subjects:After treatment in both groups,the points of IBS-QOL in each dimension can be reduced(P<0.05);During the follow-up,the scores of"anxiety","behavioral disorder","somatic awareness","food avoidance"and"interpersonal relationship"could be reduced in both groups(P<0.05),chaishen jieyu decoction ean also improve"health concems"and"social function"(P<0.05),while pivemonium bromide has no obvious effect(P>0.05);Chaishen jieyu decoction was better than pivemonium bromide in both anxiety and behavior disorder after treatment and follow-up(P<0.05).The difference of efficacy in other dimensions was insignificant(P>0.05).8.Safety comparison:There were no adverse reactions in the two groups of subjects,and the two treatments were highly safe.Conclusions:The Chinese medicine Chaishen Jieyu Decoction can effectively improve the clinical symptoms and maintain remission of patients with liver stagnation and spleen deficiency syndrome of diarrhea irritable bowel syndrome:In the short term,it can significantly reduce the anxiety of patients.Compared with the Western medicine Piveronium bromide,it has obvious advantages in treatment,indicating that Chinese medicine is an effective method for treating diarrhea-type irritable bowel syndrome. |
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