The Research On The Medication Rule Of Professor Xia Junquan In The Treatment Of Chronic Atrophic Gastritis Based On Data Mining

Objective:To summarize the regularity of medication of Professor Xia Junquan in the treatment of chronic atrophic gastritis by collecting the cases of chronic atrophic gastritis diagnosed and treated by Professor Xia Junquan,and to summarize Professor Xia Junquan’s academic thoughts on the treatment of chronic atrophic gastritisMethods:1.228 patients with chronic atrophic gastritis who met the inclusion criteria and were diagnosed and treated by Professor Xia Junquan from October 2017 to April 2019 were collected.The TCM symptom scores before and 3 months after treatment were recorded to evaluate the efficacy of traditional Chinese medicine in the treatment of CAG.2.228 cases of CAG patients’ basic information,initial diagnosis type and prescriptions were recorded into the database.Data mining methods such as frequency analysis,cluster analysis and association rule analysis were used.Combined with the clinical diagnosis and treatment experience of tutors,the medication rules and academic ideas of Xia Junquan’s treatment of CAG were summarized.Results:1.Evaluation of the curative effect of TCM symptoms:A total of 228 CAG patients who met the requirements were included in this study,and the overall response rate was 93.86%after 3 months of treatment with traditional Chinese medicine.2.General conditions:Of the 228 patients,100(43.86%)were male and 128(56.14%)were female;The age was mainly distributed between 41 and 70 years,accounting for 87.28%of the total number of patients.3.There are four types of syndromes:spleen and stomach weakness(25.56%),cold and heat syndrome(22.37%),liver depression and spleen deficiency(18.42%),Qi and yin deficiency(14.91%);228 patients had a total of 228 prescriptions,the total frequency of drug use was 3736 times,a total of 142 different traditional Chinese medicines,39 drugs were used more frequently than 30 times,accounting for 80.59%of the total drugs,of which the top ten were:Fried Radix Paeoniae Alba,Radix Curcumae,Herba Agrimoniae,Radix Glycyrrhizae,Radix Codonopsis,Dandelion,Suteri,Hedyotis diffusa,Radix Puerariae,Radix Salviae Miltiorrhizae.39 high-frequency drugs could be divided into 12 categories according to efficacy,which were tonic drugs(25.19%),antidotes(9.66%),blood-activating and stasis-dissipating drugs(8.43%),heat-clearing drugs(7.60%),Xiaoshi drugs(6.53%),water and dampness drugs(5.33%),hemostatic drugs(4.95%),Qi regulating drugs(4.10%),tranquilizers(3.67%),phlegm-relieving and anti-asthmatic drugs(2.30%),dampness-dissipating drugs(1.93%),and calming the liver and eliminating wind drugs(0.91%).4.Cluster analysis:Based on the cluster analysis of 39 high-frequency traditional Chinese medicines,four cluster combinations were obtained:First:stir fried corn sprout,stir fried malt,Dendrobium,Pseudostellaria,dandelion,Salvia miltiorrhiza,Albizia,Fu Shen,Cinnamon Twig,astragalus;Second:Fructus trichosanthis,pinellia,rhizoma coptidis,atractylodes,peregrine,tangerine peel,turmeric,bristles,fritillary bulb of thunbergii thunb,radix aconiti,lily,licorice root,radix salvia,semen raphani;Third:liushenqu,yam,bupleurum,stir fried Atractylodes macrocephala,Muxiang,stir fried coix seed,Poria cocos;Fourth:stir fried peony,tulip,stir fried licorice,dangshen,Hedyotis diffusa,pedicel,Agrimonia,Pueraria.5.Association rule analysis:Application Apriori The algorithm analyzed the association rules of 39 high-frequency drugs,with a minimum support of 40%and a minimum confidence of 80%,resulting in 8 two-drug association rules,15 three-drug association rules,and 1 four-drug association rule.Conclusion:1.Professor Xia Junquan has remarkable curative effect on CAG,which is worthy of clinical application.2.Professor Xia Junquan believes that the weakness of the spleen and stomach is the pathological basis of CAG,and the treatment is based on tonifying deficiency(supplementing qi,nourishing Yin,invigorating spleen and softening liver),paying attention to soothing liver and regulating qi.3.Professor Xia Junquan’s basic medication for CAG:spleen and stomach weakness syndrome:fried Atractylodes macrocephala,fried Coix seed,Poria cocos,yam,Bupleurum chinense,wood incense;cold and heat mixed syndrome:Coptis,pinellia,Trichosanthes,Atractylodes,Peilan,black medicine,lily,raw licorice,North ginseng;qi and yin deficiency syndrome:Radix Pseudostellariae,Dendrobium,Albizia,Fushen,stir fried corn sprout,stir fried malt;liver depression and spleen deficiency syndrome:Stir fried white peony,Codonopsis pilosula,Agrimonia,turmeric,roasted licorice.4.By combining the data mining results with the tutor interview and transcription experience,Professor Xia Junquan’s academic thought of treatment is invigorating qi and invigorating spleen,taking into account stomach yin;balancing yin and yang,taking into account both cold and heat;treating the liver and spleen together,taking into account each other;regulating emotions,taking into account both body and mind.