| Objective: to investigate the clinical efficacy,recurrence rate and mechanism of the second anwei decoction combined with quadruple therapy in the treatment of duodenal ulcer with dampness stagnation of spleen and stomach syndrome,so as to provide a theoretical basis for the treatment of duodenal ulcer with combination of traditional Chinese and western medicine.Methods: a total of 60 patients were selected in this study.According to the random number table method,the patients were divided into the treatment group and the control group,with 30 patients in each group.The treatment group was treated with the second anwei decoction combined with quadruple therapy,while the control group was treated with quadruple therapy.By observing the TCM symptom score changes,the recurrence rate,Hp eradicate rate gastroscope curative effect,serum stomach secrete hormone level changes,the recurrence rate and record adverse reactions in the process of treatment,to investigate the clinical efficacy,recurrence of ulcer andmechanism of the second anwei decoction combined with quadruple therapy in the treatment of duodenal ulcer with dampness stagnation of spleen and stomach syndrome.Results:1.General situation: the 60 patients in the treatment group and the control group included in the statistical analysis were not statistically significant in terms of age,gender and course of disease(P>0.05),which was comparable.2.Overall clinical efficacy: the total effective rate of the treatment group(96.67%)was significantly better than that of the control group(80.00%),and the difference was statistically significant(P<0.05),indicating that the overall efficacy of the treatment group was better than that of the control group.3.Improvement of symptoms:(1)Comparison of total symptom scores:(1)comparison between the two groups before treatment: there was no statistically significant difference in total symptom scores between the two groups before treatment(P>0.05),which was comparable.(2)Intra-group comparison after treatment: the total symptom score of the two groups after treatment was significantly lower than that before treatment,and the difference was statistically significant(P<0.05).(3)After treatment,the total score of symptoms in the treatment group decreased significantly compared with the control group,and the difference was statistically significant(P<0.05).(2)Comparison of scores of single symptom:(1)comparison of scores of each single symptom between the two groups before treatment:comparison of scores of each single symptom between the two groups before treatment showed no statistical significance(P>0.05).Comparable.(2)Comparison in the treatment group after treatment: the scores of each symptom in the treatment group were lower than those before treatment,and the difference was statistically significant(P<0.05).The scores of each symptom in the control group were lower than those before treatment,and the difference was statistically significant(P<0.05).The results showed that the single symptom of the two groups were significantly improved.(3)Comparison between groups after treatment: the scores of single symptoms in the treatment group was lower than that of the control group,and the difference was statistically significant(P<0.05),indicating that the treatment group was superior to the control group in improving single symptoms.4.Hp eradication rate and recurrence rate:(1)the comparison of Hp eradication rate: the treatment group was 93.33%,the control group was83.33%,the difference between the two group was not statistically significant(P>0.05),indicating that the treatment group and the control group had the same effect in Hp eradication rate.(2)In the comparison of Hp recurrence rate:the treatment group was 7.14%,the control group was 36.00%,the difference between the two group has statistical significance(P<0.05),indicating that the treatment group is better than the control group in reducing Hp recurrence rate.5.Gastroscopic efficacy: the total effective rate of the treatment groupwas 90.00%,and that of the control group was 80.00%.The difference between the two groups was statistically significant(P<0.05),indicating that the curative effect of the treatment group was better than that of the control group in terms of promoting the healing of ulcers.6.Serum gastrin level:(1)after treatment,the serum GAS level of both groups was lower than that before treatment(P<0.05),indicating that the treatment group and the control group could both reduce the serum GAS level of patients with duodenal ulcer.(2)after treatment,gastrin level in the treatment group was significantly lower than that in the control group,and the difference was significant(P<0.05),indicating that the treatment group had more advantages in reducing serum GAS level.7.Medication safety: no adverse drug reactions occurred in the two groups during the study period.8.Ulcer recurrence: six months after the end of treatment and discontinuation of drugs,the patients of the two groups who showed clinical cure and obvious effect under gastroscopy were reexamined by gastroscopy,and the results showed that the recurrence rate of the treatment group was 0.The recurrence rate of the control group was 22.22%.The difference between the two groups was statistically significant(P<0.05),indicating that the treatment group had more advantages than the control group in reducing the rate of ulcer recurrence.Conclusion:(1)the combination of the second anwei decoction combinedwith quadruple therapy can effectively improve the clinical symptoms of duodenal ulcer dampness stagnation of spleen and stomach syndrome,promote the healing of ulcer,reduce the recurrence rate of ulcer and reduce the recurrence rate of Hp,and the drug is relatively safe,worthy of clinical application.(2)The mechanism of the second anwei decoction in the treatment of duodenal ulcer with dampness stagnation of spleen and stomach may be related to the reduction of serum gastrin level in patients,which is worth further study. |
PDF Full Text Request