| Objective: To evaluate the effectivity and safety of electroacupuncture in the treatment of acute phase Bell’s paralysis and the optimal stimulation parameters of electroacupuncture in the treatment of acute Bell’s palsy by comparing each electroacupuncture groups with different parameters,electroacupuncture and ordinary acupuncture,so as to provide reference for clinical practice.Methods: This study strictly adopts the research method of Randomized Controlled Trial(RCTs),A total of 126 patients who met the inclusion criteria were randomly divided into five groups(group A: sparse-dense wave(>2Hz);Group B.sparse-dense wave(<2Hz);Continuous wave(> 2Hz);Continuous wave(< 2Hz);Group E: traditional acupuncture)by useing the computer to generate random numbers,of which 3 cases dropout during the treatment period and 8 cases drop out during the follow-up period.The five groups was received the same basic treatment,group A,group B,group C and group D was received electroacupuncture with different parameters,such as waveforms and frequencies,and group E was received traditional acupuncture treatment,6 times of treatment per week for one course and take a break once a week.The efficacy of each group was compared before treatment,after 2 courses of treatment and after 4 courses of treatment,and the treatment results were evaluated by using the House-Brackmann(H-B)grade scale,the H-B partial quantitative scale and the TCM symptom score.Follow-up evaluation was conducted at 5 weeks,2 months and 3 months after enrollment.Spss 21.0and Graphpad 8.0.1 were used to collate,analyze and plot the data statistically.Results:1.baseline data:There was no statistically significant difference in baseline data of each groups(case source,gender,age,disease course,disease location)(P>0.05),which was comparability.2.H-B grade scale:Patients in group A,group B,group C,group D and group E were evaluated after observation of 2 courses of treatment(W2)and 4 courses of treatment(W4).Compared within the group,all the treatment methods in the five groups were able to improve the functional classification of facial nerve of Bell’s palsy in different courses of treatment,and the difference was statistically significant(P<0.05).Comparison among groups,there was no statistically significant difference between the groups(P > 0.05).3.H-B partial quantitative scale:Compared within the groups:After 2 courses of treatment(W2)and 4 courses of treatment(W4),the total score,forehead,eye,buccal and mouth Angle of H-B partial quantization score of patients in group A,group B,group C,group D and group E were all decreased.all the treatment methods in the five groups could effectively improve the overall function and the local function of forehead,eyes,buccal and mouth Angle of patients with acute Bell’s palsy,indicating that all the five treatment methods were effective,and the difference was statistically significant(P < 0.05).Comparison among groups:At the second course of treatment,the effect of treatment in group A on improving the overall function and forehead function of patients with acute Bell palsy was better than that in group E(P< 0.05),while there was no difference between the other groups in improving the overall function and forehead function of patients with acute Bell palsy after different courses of treatment(P > 0.05);At the second course of treatment,the effect of treatment in group A was better than that in group C,group D and group E in improving the eye closure function of patients with acute Bell palsy(P<0.05),while the other groups showed no difference in improving the eye closure function of patients with acute Bell palsy after different courses of treatment(P > 0.05).There was no difference in the improvement of buccal and mouth Angle function in patients with acute Bell’s palsy after 2 courses of treatment(W2)and 4 courses of treatment(P > 0.05).4.TCM symptom score:Patients in group A,group B,group C,group D and group E were evaluated after 2courses of treatment(W2)and 4 courses of treatment(W4)respectively.Compared within the group,all the treatment methods in the five groups were able to improve TCM symptoms in patients with acute Bell’s palsy,the statistically significant difference(P <0.05);the difference was statistically significant(P<0.05).Comparison among groups:the efficacy of group A was significantly better than that of group E after 2 weeks of treatment,with statistically significant difference(P < 0.05).The other groups were evaluated after different courses of treatment,with no statistical difference(P > 0.05).5.Curative effect evaluation:After 2 courses of treatment(W2)and 4 courses of treatment(W4),the treatment method was effective in all 5 groups of patients in groupA,group B,group C,group D and group E there was no statistically significant difference(P > 0.05),after 2 courses of treatment: group A,group B,group C,group D and group E,total effective rate were 88.0%,76.9%,69.9%,61.9%,68.0%;After 4 courses of treatment,the total effective rates of group A,group B,group C,group D and group E were 100.0%,96.1%,96.1%,100.0%and 92.0%,respectively.6.Comparison of treatment times of patients who recovered after 4 courses of treatmentAverage treatment times of each group: group A(19±4.75),group B(21±5.19),group C(22.55±3.70),group D(23.33±1.41),and group E(23.30±1.49),The number of times of recovery after 4 courses of treatment in group A was significantly lower than that in group C,group D and group E,and the difference was statistically significant(P < 0.05).7.Follow-up evaluation:For in patients after follow-up for 3 times,2 patients(group C 1 case,1 case of group E)in the group of 5 weeks follow-up facial paralysis sequelae,1 case of muscle spasm(group C),1 case appeared synkinesis group(E).1 case of patients(group C 1)in the group of 2 months and 3 months follow-up have facial palsy sequelae(and the follow-up for the first time for the same patient),shows that both normal acupuncture and electroacupuncture treatment acute Bell’s palsy have very low probability of occurrencesequela,three follow-up,groups of patients with H-B classification,there were no statistically significant difference(P > 0.05).8.Safety evaluation: all patients showed no abnormal of safety indicators,and no serious adverse reactions occurred during the treatment.Conclusion:1.Electroacupuncture and traditional acupuncture were safe and effective in the treatment of acute Bell’s palsy in the acute stage,with no difference in the overall efficacy;2.The sparse-dense wave electroacupuncture and with the frequency of greater than 2HZ was better than the ordinary acupuncture group in improving the TCM symptoms of patients with acute Bell’s palsy in the early stage of the disease(within 2-3 weeks);3.In the early stage of the disease(within 2-3 weeks),the sparse-dense electroacupuncture and the frequency of greater than 2HZ were superior to the normal acu Puncture group in improving the forehead function of patients with acute Bell’s paralysis,and superior to the normal acupuncture group and the continuous wave electroacupuncture group in improving the eye closure function of patients with acute Bell palsy.4.the sparse-dense electroacupuncture and the frequency of greater than 2HZ,the average recovery times of Bell’s palsy in the acute stage intervention was 19±4.75,which was lower than that of the ordinary acupuncture group and other electroacupuncture parameter groups. |
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