| Purpose:Retrospective analysis of relevant clinical factors and imaging data of 35 patients with laryngeal cancer admitted in our hospital.Further clarify the relationship between the maximum standardized uptake value of 18F-FDG PET/CT and clinical factors related to laryngeal squamous cell carcinoma.The aim is to provide certain reference value for the judgment of clinical stage of laryngeal cancer,the choice of treatment methods and the evaluation of disease prognosis.Method:All patients were diagnosed as laryngeal squamous cell carcinoma by pathological biopsy before surgery.A whole body 18F-FDG PET/CT examination was performed in the nuclear medicine department of our hospital 1 week before the operation.The clinical and pathological characteristics of patients with laryngeal cancer were collected,such as gender,age,pathological grade,TNM stage,whether accompanied by lymph node metastasis,tumor diameter,etc.,and the corresponding SUVmax values of primary foci were recorded.The measurement data are tested for normality,which are expressed in accordance with the normal distribution mean±standard deviation.The grouped variables are tested for homogeneity of variance,followed by t test,one-way analysis of variance,Pearson correlation analysis,and multi-factor analysis.In the scientific test,P<0.05 is considered statistically significant.Result:Univariate analysis showed that there was no statistically significant difference in the SUVmax value of primary tumors in patients with laryngeal cancer of different genders（P=0.260）;There was also no significant difference in the SUVmax value of the primary tumor between patients with laryngeal cancer aged less than 60 years and those aged 60 years or older（P=0.131）;For patients with laryngeal cancer with and without lymph node metastasis,the difference between the primary SUVmax values was statistically significant（P<0.01）;The difference in the SUVmax value of the primary tumor between the different pathological grade groups（highly differentiated group,moderately differentiated group,and poorly differentiated group）was statistically significant（P<0.01）;The difference between the SUVmax values??of the primary laryngeal cancer in different clinical stages（stagesⅠ,Ⅱ,Ⅲ,andⅣ）was statistically significant（P<0.01）.The fitted curve analysis showed that there was a linear positive correlation between the SUVmax value of the primary cancer of the laryngeal carcinoma and the tumor diameter.Multivariate analysis suggested that pathological grade was an independent influencing factor of the SUVmax value of the primary laryngeal squamous cell carcinoma,and TNM stage and tumor diameter were not independent factors of the SUVmax value of the primary laryngeal cancer.The ROC curve analysis suggested that the SUVmax value of the primary laryngeal cancer has certain diagnostic power for predicting the lymph node metastasis of the laryngeal cancer.Conclusion:There is a certain correlation between the SUVmax value of the primary tumor of laryngeal cancer and certain clinical factors.The lower the pathological grade,the higher the clinical stage,the larger the tumor diameter,and the lymphoma metastasis in patients with laryngeal cancer,the higher the primary SUVmax value.You can use this to make a more accurate judgment on the clinical stage,treatment and prognosis of patients with laryngeal cancer. |
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