| ObjectivesBased on analysis the correlation of parathyroid hormone(iPTH)levels and hemoglobin(Hb)and hematocrit(Hct)levels in patients with chronic kidney disease,to explore whether the levels of iPTH in patients with CKD is one of the causes of the hemoglobin level decreased.The aim is to provide a new perspective for the treament and prevention of renal anemia in patients with chronic kidney disease.MethodsThe experiment group: From January 2014 to December 2016,90 cases of chronic kidney disease were recruited in Division of Nephrology,Affiliated Hospital of Taishan Medical University,includes 49 men,41 women,mean age,59.82 years(range from19 to 78 years).EGFR was calculated by Modification Diet In Renal Disease(MDRD)formula,and divided into CKD1-2 group,CKD3-4 group and CKD5 group according to the criteria of chronic kidney disease.The control group: 30 healthy volunteers are demonstrated by physical examination(male13,female17),with a mean age of 53.87 years(range from 28 to 75).Among patients taking angiotensin converting enzyme inhibitors,non steroid antiinflammatory drug,iron,erythropoietin,glucocorticoid,vitamin D,their analogues,and various causes of bleeding were excluded.The clinical data were collected such as age,sex and weight,hemoglobin,hematocrit,serum calcium,serum phosphorus,serum creatinine,Blood urea nitrogen,serum albumin,the systolic pressure,the diastolic pressure,parathyroid hormone(iPTH).Statistical methods: using SPSS18 statistical analysis software to process the data.Results1.Compared with the control group and CKD group,serum TC and TG has little chang.But Serum calcium,Hb,Hct decreased gradually with renal function deteriorated.iPTH gradually increased from CKD1-5 phase,the 5 phase was significantly higher than other groups.2.In stages 1-5 of CKD and control group,There was no statistically significant difference between age,gender,weight,levels of serum TC and TG(P>0.05).The systolic pressure in stages 3-5 of CKD is higher than the stages 1-2 of CKD and control group and The diastolic pressure in stages 5 of CKD is higher than the stages 1-4 of CKD and control group,(P<0.05).In stages 1-2 of CKD and control group,There was no statistically significant difference of the serum Alb(P>0.05).The serum Alb in stages 3-5 of CKD is higher than the stages 1-2 of CKD and control group,(P<0.05).3.In stages1-4 of CKD and control group,There was no statistically significant difference between serum Ca and P(P>0.05).The levels of serum Ca decrease from 2.28±0.15mmol/L in stages of CKD 1-2 to 2.00±0.24mmol/L in stage of CKD5.However,the levels of serum P and Ca×P increase from 1.38±0.12mmol/L and 3.13±0.35 in stages of CKD1-2 to 2.30±0.99mmol/L and 4.616±2.08 in stage of CKD5.So,in stages 5 of CKD,Ca is lower than the stages 1-4 of CKD and control group,P and Ca×P are higher than the stages 1-4 of CKD and control group,(P<0.05).4.In stages1-2 of CKD and control group,There was no statistically significant difference between iPTH、Hb and Hct(P>0.05).With the decline of renel function,iPTH increased gradually,from 39.67±9.260pg/mL in stage of CKD1-2 to 475.41±285.51pg/mL in stage of CKD5.In stages 3-5 of CKD,iPTH is higher than the stages of CKD1-2 and control group,(P<0.05).In stage of CKD1-2,Hb and Hct decrease from 120.30±9.57 g/L and 0.42±0.07 in stages of CKD 1-2 to 80.13±20.52g/L and 0.24±0.06 in stage of CKD5,the difference was statistically significant(P<0.05).5.Pearson correlation analysis revealed,during CKD 1-5stages,iPTH was negatively correlated with serum Ca(r=-0.635,P<0.01),iPTH was positively correlated with serum P(r=0.557,P<0.01),and iPTH was negatively correlated with Hb and Hct(r=-0.635 and-0.585,P <0.01).ConclusionsWith the decline of renel function,iPTH was increased,HB and Hct was declined gradually.iPTH can lead the decline of Hb and Hct.As a result,the higher levels of iPTH was one of reasons that make anemia severe. |
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