High-throughput Sequencing Of Individualized Chemotherapy And Drug Sensitivity-related Genes In Patients With Oral Squamous Cell

Objective: To explore the relationship between the sensitivity of chemotherapy drugs and the outcome of chemotherapy through high-throughput sequencing to provide guidance for individualized chemotherapy for patients with oral squamous cell carcinoma.Methods: 26 patients who were diagnosed with oral squamous cell carcinoma by preoperative pathological report in Xinjiang Uyghur Autonomous Region were selected,and the surgical resection specimens of these 26 patients were detected by high-throughput sequencing technology for 19 ERCC1 and other chemotherapy-related drug target genes,and the oral cavity was analyzed.The sensitivity of patients with squamous cell carcinoma to various chemotherapy-related drugs.All patients received chemotherapeutic regimen +platinum + vinblastine chemotherapy.The clinical chemotherapy effect was evaluated by the size of the patient’s tumor and the presence of calcification in the tumor.Results: The effective rate of chemotherapy in 26 patients was 61.5%(16/26).Drug sensitivity genetic testing showed that 24 patients with oral squamous cell carcinoma were sensitive to boxomycin with a sensitivity rate of 92.3%;20 patients were sensitive to methotrexate with a sensitivity rate of 76.9%;17 patients were sensitive to paclitaxel and vinblastine.The sensitivity rate was 65.4%;18 cases were sensitive to cyclophosphamide with a sensitivity rate of 69.2%;9 cases were sensitive to platinum and the sensitivity rate was34.5%;4 cases were sensitive to anthracyclines with a sensitivity rate of 15.4%;3 cases were sensitive to tamoxifen with a sensitivity rate of 11.5%;12 cases were sensitive to5-fluorouracil / capecitabine with a sensitivity rate of 46.2%;15 cases were sensitive to letrozole / anatrozole with a sensitivity rate of 57.7%.Conclusion: Individuals of oral squamous cell carcinoma vary greatly,and each chemotherapy drug has its own specific sensitive population.Patients whose genes are sensitive to multiple chemotherapy drugshave higher chemotherapy efficacy than patients who are only sensitive to single drugs.Precise individualized chemotherapy for patients with oral squamous cell carcinoma may become one of the effective methods to improve the effect of chemotherapy.