Clinical Study Of Jieyuhewei Formulae In Treatment Of Refractory Gastroesophageal Reflux Disease(Liver Stomach Heat Stagnation Type)

Objective:Through statistical analysis,this paper explores the clinical efficacy of jieyuhewei Decoction in the treatment of refractory gastroesophageal reflux disease(ganweiyure type),so as to provide objective basis for the clinical promotion of jieyuhewei decoction,and provide new ideas for the further study of the mechanism of action of the disease in the future based on the treatment methods and pharmacological effects.Methods:64 cases of refractory gastroesophageal reflux disease(liver stomach stagnant heat type)were randomly divided into treatment group and control group according to the proportion of 1:1.After the basic treatment,the treatment group was given Jieyu Hewei decoction free decoction,and the control group was given esomeprazole enteric coated capsule and mosapride citrate tablet.The treatment period was 8 weeks.The treatment of the two groups was compared Before and after treatment,the total score of symptoms of traditional Chinese and Western medicine,the degree distribution of single symptoms of traditional Chinese medicine,HRM,24 h esophageal pH,endoscopic results,SAS and SDS scores were statistically analyzed.Results:By spss22.0 software test,there was no significant difference in baseline data between the treatment group and the control group before treatment.After treatment,there was significant statistical difference between the two groups before and after treatment.After treatment,the comparison between the two groups showed that the total effective rate of the treatment group was 93.10% and that of the control group was 67.67%;the total effective rate of the treatment group was 82.76% and that of the control group was 60.00%.Therefore,jieyuhewei decoction was better than esomeprazole enteric coated capsule and mosapride citrate tablets in the overall physical treatment of traditional Chinese and Western medicine.After treatment,the treatment group was superior to the control group in terms of the total score of Chinese and Western Medicine symptoms,the degree distribution of single symptom of traditional Chinese medicine except the symptom of pain behind the sternum,HRM results,24-hour esophageal pH monitoring results(exceptthe frequency of acid reflux,the proportion of acid reflux),SAS and SDS scores.The frequency and proportion of acid reflux in the control group were better than those in the treatment group.There was no significant difference between the two groups after treatment.According to the results of endoscopy before treatment,the subjects in the treatment group and the control group were divided into nerd group and re group.The subjects in the treatment group and the control group were analyzed before and after treatment to evaluate the total score of Western Medicine symptoms,the total score of traditional Chinese medicine syndromes,and the degree of disease distribution of single symptoms in traditional Chinese medicine.After treatment in Re Group,the comparison of Western medicine symptom total score,traditional Chinese medicine symptom total score,heartburn and belching symptom between the two groups indicated that the therapeutic effect of the treatment group was significantly better than that of the control group;the comparison of acid regurgitation,sternal pain,irritability and irritability symptom with endoscopy results showed that there was no significant statistical difference between the two groups.After treatment in nerd group,the total score of Western medicine,Chinese medicine,anti acid,heartburn,belching,irritability and irritability between the two groups showed that the curative effect of the treatment group was significantly better than that of the control group.There was no significant statistical difference between the two groups in the symptom of pain behind the sternum.During the experiment,there were 1 case in the treatment group and 2 cases in the control group.It is suggested that jieyuhewei decoction is safe and reliable in clinical application.Conclusion:Jieyuhewei decoction is superior to esomeprazole enteric coated capsule and mosapride citrate tablets in the treatment of refractory gastroesophageal reflux disease of liver stomach heat stagnation type,with significant effect and high safety in clinical use.