Clinical Study Of Jiedu Tongluo Tiaogan Anshen Decoction In Treating Type 2 Diabetes Complicated With Insomnia (Syndrome Of Liver Depression Transforming Into Fire)

Objective:Observe and summarize the clinical experience of Professor Pu Chunli using Jiedu Tongluo Tiaogan Anshen Decoction in the treatment of type 2 diabetes with insomnia(Syndrome of liver depression transforming into fire).Objectively evaluate its effectiveness,safety,and treatment advantages in the treatment of type 2 diabetes with insomnia,so as to provide feasible treatment methods and objective theoretical basis for clinical practice.Methods:Sixty patients with type 2 diabetes and insomnia who met the inclusion criteria were randomly divided into two groups,including 30 in the treatment group and 30 in the control group.Both groups were given basic hypoglycemic treatment.The treatment group was given dexazopiclone combined with Jiedu Tongluo Tiaogan Anshen Decoction,and the control group was given dexazopiclone.The treatment time was 4 weeks.Changes in TCM syndrome scores,Pittsburgh sleep index(PSQI),blood glucose(fasting and 2 hours postprandial venous blood glucose),glycated hemoglobin and dexzopiclone dosing rates were monitored in the two groups.After discontinuation of the drug,the follow-up period was 4 weeks,and the relapse rate of insomnia was discontinued.Comprehensive statistical analysis of various indicators and draw conclusions.Results: in terms of symptoms,the treatment group was significantly better than the control group,especially in the main symptoms,such as restlessness,insomnia,suffering and dry throat(P <0.05).In the facultative syndrome,red face with red ears,excessive drinking of thirst,fullness of both threats,and redness in constipation(P <0.05)were statistically significant(P <0.01).In terms of blood glucose,fasting blood glucose and2-hour postprandial blood glucose were significantly lower in the treatment group than in the control group(P <0.01),and the effect of glycated hemoglobin was equivalent(P>0.05).The Pittsburgh sleep quality index score and the scores of the other factors excluding sleep disturbance factors were significantly lower in the treatment group than in the control group(P <0.05),which was statistically significant.The relapse rate and dexzopiclone dosing rates was significantly lower in the treatment group than in the control group(P<0.05).No adverse reactions were found before and after treatment in both groups.Conclusion:The effect of Jiedu Tongluo Tiaogan Anshen Decoction combined with western medicine is significantly better than that of western medicine alone.Traditional Chinese medicine treatment can significantly improve the clinical symptoms of type 2diabetes with insomnia(stagnation of liver stagnation and fire syndrome),improve patients’ sleep quality,sleep efficiency,and day Function,increase sleep time,reduce Western medicine usage rate the recurrence rate,at the same time is conducive to blood glucose control,prevent complications,effectively improve the quality of life of patients,and is safe and effective.It has a wide application prospect,and it is worthy of promotion and in-depth clinical research.