Clinical Study On The Relationship Between Helicobacter Pylori Infection And C-reactive Protein And Abdominal Allergic Purpura In Children

Objective:To investigate the changes of Helicobacter pylori(Helicobacter pylori,Hp)infection and c-reactive protein(C-reactive protein,CRP)in children with abdominal henoch-schonlein Purpura(Henoch-Schonlein Purpura,HSP)and to analyzethe relationship between the two and children with abdominal henoch-schonlein Purpura(HSP),so as to provide theoretical basis for clinical treatment and reduction of recurrence.Methods:A retrospective analysis was performed on 170 cases of HSP hospitalized in our hospital from March 2017 to March 2019.According to the clinical type,78 cases were abdominal HSP and 92 cases were non-abdominal HSP.In addition,80 healthy children who came to our hospital for physical examination were taken as the normal group.All of them were tested by 13C breath test for HP infection,and serum CRP was determined by immunofluoroscopy turbidimetry.Meanwhile,according to different clinical treatment methods,the Hp positive children with abdominal HSP were divided into control group and treatment group.30 patients in the control group received basic symptomatic treatment,and 40 patients in the treatment group received anti-hp treatment on the basis of basic treatment.After 2 weeks of treatment,the therapeutic effect of the two groups was compared and analyzed,and the positive rate of Hp and the improvement of CRP were measured.The patients in the two groups were followed up for 6 months to observe their recurrence.Results:1.Compared with the normal group,the positive rate of Hp in HSP children was 54.12%(92/170),and the difference was statistically significant(P<0.05).Compared with the normal group and the non-abdominal HSP group,the positive rate of Hp in the abdominal HSP group was 76.09%(70/92),and the difference was statistically significant(P<0.05 for both groups).2.Compared with the normal group,the serum CRP level of the children with HSP was(36.37±2.28)mg/L,and the difference was statistically significant(P<0.05).Compared with the normal group and the non-abdominal HSP group,the serum CRP level in the abdominal HSP group was(38.18±2.28)mg/L,and the difference was statistically significant(P<0.05 in both groups).3.Compared with the control group,the total effective rate of clinical treatment in the treatment group was 92.50%significantly increased,and the follow-up recurrence rate was 5.00%significantly reduced,with statistically significant differences(P<0.05)4.Compared with the control group,the positive rate of Hp in the treatment group was significantly reduced,and the difference was statistically significant(P<0.05).There was no significant difference in serum CRP level between the two groups before treatment(P>0.05),but the difference was statistically significant in the treatment group compared with the control group after treatment(P<0.05)5.Correlation analysis results showed that the occurrence of pediatric abdominal HSP was positively correlated with Hp infection and CRP(P<0.05).Conclusion:1.HP infection and CRP elevation are related to the occurrence of pediatric HSP,especially the occurrence of pediatric abdominal HSP.2.Anti-hp treatment can effectively improve the therapeutic effect of HSP in hp-positive children with abdominal type,promote the prognosis of the disease,and help prevent and reduce recurrence.