| Professor Xu Hefen is the chief physician and doctoral supervisor of Jiangsu integrated traditional Chinese and Western medicine hospital.He is a famous Chinese medicine teacher in Jiangsu Province.He enjoys the special allowance of experts of the State Council.Professor Xu has been engaged in the prevention and treatment of cancer with integrated traditional Chinese and Western medicine for nearly 50 years.He has rich clinical experience and profound academic attainments.He is good at using traditional Chinese medicine and integrated Chinese and Western medicine to treat cancer patients with complications after anti-tumor treatment.Xu believes that the main causes of oral mucositis after the use of anti-tumor drugs are the accumulation of heat in the heart and spleen,yin deficiency and toxic heat,and the main treatment methods are clearing heat and purging fire,nourishing yin and detoxifying.On the basis of Professor Xu’s academic thought of syndrome differentiation and treatment of oral mucositis after chemotherapy,the research team of this project made a new prescription of Shamai spray.This prescription was derived from the throat monograph of Zheng Meijian in Qing Dynasty,namely,Chonglou Yuyao,Yangyin Qingfei Decoction(Shengdi,Maidong,liquorice,Yuanshen,Fritillaria,Cortex Moutan,peppermint,fried Paeonia alba),and the prescription of Shashen Maidong Decoction(Radix et Rhizoma,Radix Ophiopogonis,Radix Glycyrrhizae,Rhizoma Fritillariae,Cortex Moutan,stir fried Radix Paeoniae Alba)written by Zheng Meijian in Qing Dynasty:Hippophae rhamnoides,Ophiopogon japonicus,Cortex Moutan,etc.are designed to observe the clinical curative effect,while inheriting and innovating the academic thoughts of famous TCM doctors.[Objective]to observe the curative effect of Shamai spray on oral mucositis of yin deficiency toxin heat type caused by antineoplastic drugs.[Methods]sixty patients with oral mucositis of yin deficiency toxin heat type were randomly divided into experimental group and control group with informed consent.Experimental group:patients were given routine oral care,health education and diet guidance.Patients with obvious pain were asked to take liquid or semi liquid diet;patients with severe ulcer and mucosal damage were asked to increase protein and vitamin intake;patients were asked to increase the amount of drinking water,which could lead to 3000ml or more.After each meal,they were given warm boiled water to gargle,and after gargling,the local spray of Shamao spray was applied to the oral mucosa injury 2-3 sprays each time,three times a day,containing it in the mouth for about 15 minutes and then spit out.After spraying,water and food were forbidden for 1 hour.Control group:conventional use of watermelon cream spray treatment:the watermelon cream spray was sprayed on the mucosal injury site,3 times a day,2-3 times each time.Other specific requirements and precautions were the same as those of the treatment group.Course of treatment:the course of treatment was 1 week in both groups.The severity of oral mucositis and ulcer and the degree of pain reaction of the two groups were observed,and the curative effect was evaluated every 3 days.[Results]according to WHO criteria for acute and subacute toxicity of anticancer drugs.CTCAE 5.0 was used to evaluate the clinical efficacy of the two methods.The severity of oral mucositis was graded as 0-Ⅳ.after treatment,the degree of oral mucositis in the experimental group and the control group could be reduced after treatment,and the curative effect of the experimental group was significantly better than that of the control group,the differences were statistically significant.(P<0.05)。Referring to the fourth edition of oral mucosal diseases,oral mucositis was divided into three typical oral signs:hyperemia and edema area,ulcer area and erosion area.The area changes of three typical signs in the experimental group and the control group before and after treatment were recorded and evaluated,and the outlet cavity sign score was calculated.The results showed that the oral sign scores of the experimental group and the control group were significantly decreased After treatment,the oral signs score decreased by about 5.7 points in the control group,and decreased by 3.3 points in the control group.Both groups had therapeutic effects,and the differences were statistically significant.(P<0.05)the observation on the changes of three typical clinical signs of oral mucositis after treatment showed that the area and grade of congestion and edema in the two groups after treatment were significantly reduced and decreased,and the effect of the experimental group with salmetel spray was significantly better than that of the control group,the difference was statistically significant.(P<0.05)after treatment,the ulcer rate and erosion rate of the two groups decreased after treatment,and there was no significant difference between the two groups before and after treatment.(P>0.05)。For patients with oral mucositis accompanied with pain,the VAS score of the experimental group was 5.1 points before treatment,and the average VAS score of the control group was 5.1 points before treatment;the average VAS score of the experimental group was 1.5 points after treatment;the average VAS score of the control group was 3.6 points after treatment.The results showed that both the sand wheat spray and the watermelon cream spray could reduce the pain,and the effect of the sand spray was better,The difference was statistically significant.(P<0.05)。[Conclusion]Shamai spray can reduce the symptoms of oral mucositis of yin deficiency and toxin heat type caused by antineoplastic drugs,and relieve the pain of patients to a certain extent. |
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