Effect Of Dexmedetomidine In Combined With Ropivacaine For Pectoral Nerve Block Ⅱ On Enhanced Recovery After Modified Radical Mastectomy

Objective To investigate the effect of dexmedetomidine(Dex)in combined with ropivacaine Pectoral nerve Ⅱ(PECS Ⅱ)block on enhanced recovery after surgery in patients undergoing modified radical mastectomy.Methods One hundred and two patients for modified radical mastectomy,were randomly divided into 3 groups(n=34 each)using a random table:normal saline group(group C),Ropivacaine group(group R),Dexmedetomidine combined with Ropivacaine group(group RD).Patients in group C received PECS II block with normal saline 30 ml,group R received PECS II block with 0.375%ropivacaine 30 ml,group RD received PECS II block with 0.375%ropivacain and dexmedetomidine 1μg/kg in 30 ml after receiving general anesthesia.The dosages of propofol and remifentanil during operation,T-painless(the time from the end of operation to the beginning of pain),immediate pain score,the max pain score during 48 hours post-operation,administration of supplemental analgesia and adverse events were recorded.Results Compared with group C and group R,the patients in group RD had longer painless time(890.6±214.6min,P<0.05),less incidence of postoperative nausea and vomiting(6%,P<0.05)and shorter carminative time(4.3±1.5h,P<0.05).Compared with group C,group R and group RD had less consumption of anesthetic perioperatively,shorter PACU stay time and hospital stay after operation,the immediate pain score and highest postoperative pain score was also lower.There was no serious hypotension or bradycardia in all groups.Conclusions Dex as an adjuvant in PECS Ⅱ block can provide longer analgesic time,better analgesic effect,shorter carminative time and enhanced recovery after surgery for patients undergoing modified radical mastectomy.