| ObjectiveThis study was based on the data from the domestic antibacterial drug database(2012-2018)for analysis,by understanding the past seven years in Beijing area new characteristics and trends of antibiotic drug consumption,the change of the analysis and evaluation of antimicrobial drug consumption,in order to find new features and reasons,assist in analyzing the problem such as the rise of drug resistance.And provide data support for promoting rational clinical drug use or adjusting management decisions on antibiotics for government.MethodRelevant data is collected through PDB drug comprehensive database,and the system collected drug purchase data of grade hospitals in key cities in China.Through the function of retrieval,the hospital of Beijing(the system includes data of 46 hospitals in Beijing: 36 hospitals of grade Iii and Grade A;there are 9 hospitals of Grade II and Grade A;A hospital 1),analysis was made on the data related to antibacterial drug use from 2012 to 2018,including key information such as the generic name,dosage form,specification,route of administration,and amount of medicine.The world health organization(WHO)anatomical therapeutic chemistry system(ATC)classification standard was used to classify antibiotics and anti-tuberculosis drugs in the antimicrobial agents.The average daily drug dose(DDD)of adults was used to classify and summarize different drug delivery routes and different drug specifications.Drug use tendency was analyzed by drug frequency(DDDs).Defined daily cost(DDC)should reflect the average daily cost of the drug.The order ratio of amount and medication frequency(B/A)was used to analyze the synchronization of medication frequency and price.Statistical data was compiled and entered into Excel 2003 for descriptive statistical analysis.The standardized sales volume was unit quantity × unit dose(g).The year was the independent variable,and the amount or frequency of drug use was the dependent variable.A linear regression model was constructed to analyze the time trend of drug use.SPSS 22.0 was used for linear regression analysis,and the trend of drug use with each year was estimated according to the regression coefficient of the model,and P<0.05 was considered as statistically significant Results1.The sales amount of antibiotics in Hospitals in Beijing from 2012 to 2018 shows that the total sales amount of antibiotics has been decreasing year by year since 2014(?<0,P=0.009).Among them,injectable antibiotics showed a downward trend(?<0,P=0.003),and the sales amount of oral antibiotics remained stable(P=0.128).The sales amount of antibiotics injected with antibiotics is always higher than that of oral antibiotics,and is 2 ~ 3 times higher than that of oral antibiotics.2.From 2012 to 2018,the sales volume of antibiotics in hospitals in Beijing showed that the total sales volume fluctuated up and down in a small range,and the total sales volume basically changed steadily.The order of composition proportion of different classes of antibiotics remained basically unchanged,and the composition proportion changed to some extent.The most obvious decrease was that of cephalosporins,whose composition proportion decreased by 7%,and the antibacterial combination increased by 3%.From 2012 to 2018,the daily DDD value per 100 patients increased year by year(P=0.033).3.The analysis results of different types of antibiotics in Beijing regional hospitals from 2012 to 2018 showed that the types of drugs available in hospitals in 2018 were significantly lower than those in 2012.Tetracycline,Chloramphenicol,Penicillin,Cephalosporin and other antibiotics have some drug frequency intensity increase,fixed day price is unreasonable,concentrated long-term use of the situation.4.Analysis of Anti-tuberculosis drug sales in Beijing hospitals from 2012 to 2018 shows that the sales amount increases year by year,and the sales volume drops slowly after reaching the peak in 2016.In 2012,compared with 2018,the composition of anti-tb drugs did not change much,and the composition of sales amount of various drugs changed greatly.Anti-tuberculosis drugs were mainly first-line and oral,and second-line and injection drugs were supplemented,and the sales amount of second-line drugs,DDDs and injection drugs showed an increasing trend(all P<0.05).The unit price of antibiotics is the biggest economic burden of the injection category.Moreover,compared with 2012,the price of most kinds of antibiotics has increased to different degrees in 2018.Conclusion1.In general,the total amount of antibiotic sales in Beijing shows a downward trend;the total sales volume shows a small fluctuation;the frequency and intensity of antibiotic use have a certain increasing trend,and the sales amount of some antibiotics on a limited day is high.This indicates that the government has a certain role in regulating and managing the policies of antibiotics,but a series of normative measures should be taken to deal with the abuse of antibiotics.2.The frequency of drug use of anti-TB drugs in Beijing remained stable from 2012 to 2018,but the daily consumption amount of most anti-TB drugs showed an increasing trend,the economic burden of patients increased,and the use of anti-TB drugs was concentrated,so the risk of drug resistance could not be ignored. |
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