Effects Of Shutaishu On Inflammatory Factors And Peritoneal Adhesions After Cesarean Section

Objective:The formation of adhesion is one of the postoperative complications of gynecology,which can lead to small intestinal obstruction,infertility,chronic pelvic pain,etc.,and also increase the difficulty of reoperation.The formation mechanism of pelvic adhesion is complex,the therapeutic effect is not ideal,and the reoperation is difficult.Therefore,the exploration of preventive measures has become the focus of abdominal and pelvic surgery.This paper analyzes the effects of two different drugs,normal saline and sutaisu,on the prevention of pelvic and abdominal adhesions during cesarean section,and seeks for a better method to prevent pelvic and abdominal adhesions after cesarean section.Methods:102 cases of parturient women who underwent the second cesarean section in Wuxi Third People’s Hospital from 2017 to 2018,and the first cesarean section was also performed in the hospital,were collected and divided into two groups according to the different drugs used to prevent pelvic and abdominal adhesions after cesarean section:the sutaishu group(59 cases)and the control group(43 cases).In the sutaishu group,sutaishu was put into the abdominal cavity and lavage before cesarean section.In the control group,the pelvic cavity was washed with normal saline before cesarean section.The incidence rate of postoperative chronic pelvic pain were observed in the two groups of puerpera after cesarean section.Microcirculation indexes,including erythrocyte aggregation rate,were measured.Immunohistochemical method was used to detect the changes and differences of TGF-beta 1,VEGF and MMP-9 expressions in serum of the two groups.The pelvic and peritoneal adhesions were observed during the second cesarean section,including the severity and scope of the adhesionsResults:(1)After the first cesarean section,the postoperative anal exhaust time of the shutaishu group was slightly shorter than that of the control group,but there was no statistical significance(P>0.05).The postoperative anal defecation time of the shutaishu group was significantly shorter than that of the control group,and the difference was statistically significant(P<0.05).The postoperative feeding condition of the shutaishu group was significantly better than that of the control group,and the statistical difference was very significant(P<0.05).The incidence of periodic abdominal pain was lower,with statistically significant differences(P<0.05).There were no statistically significant differences in fibrinotin,whole blood viscosity,erythrocyte aggregation index,hematocrit and K value between the two groups of women before operation(P>0.05).The postoperative values of fibrinogenin,whole blood viscosity,erythrocyte aggregation index,hematocrit,and esr K in the shutaishu group were significantly lower than those in the control group,with statistically significant differences(P<0.05).There was no significant difference in the expression levels of TGF-beta 1,VEGF and MMP-9 between the two groups of women before operation(P>0.05).The expression levels of TGF-beta 1 and VEGF in the shutaishu group were significantly lower than those in the control group,and the expression levels of MMP-9 were significantly higher than those in the control group,with statistically significant differences(P<0.05).(2)Pelvic adhesion during the second cesarean section:there were 10 cases(16.95%)of pelvic adhesion in the sutaisu group and 17 cases(39.53%)in the control group,with statistically significant differences(P<0.05).Conclusion:Sutaishu can effectively reduce the expression of inflammatory factors in parturient women,and can also play a good role in preventing parturient pelvic and peritoneal adhesions,and its safety is relatively high,which is worth promoting in clinical practice.