Correlation Analysis Between Hypomagnesemia And Early Hematoma Volume As Well As Condition At Admission Of Intracerebral Hemorrhage

Objective To investigate the correlation between initial hematoma volume,condition at admission and hypomagnesemia in patients with intracerebral hemorrhage(ICH).Methods We selected patients with intracerebral hemorrhage who were admitted to the neurological wards of the Second Affiliated Hospital of Anhui Medical University within 6hours of onset from February 2017 to May 2018 and met the diagnostic criteria for intracerebral hemorrhage were.After admission,head computerized tomography(CT)examination,serum magnesium concentration measurement and laboratory examination were completed,and baseline data including gender,age,blood pressure,previous history,anticoagulation history,smoking history and drinking history were collected.According to the normal reference value of blood magnesium concentration in the laboratory,the patients were divided into the low blood magnesium group<0.75mmol/L and the normal blood magnesium group(0.75mmol/L～1.25mmol/L).The volume of hematoma at admission was calculated using the Tada Formula,and the critical condition at admission was evaluated according to the Glasgow Coma Scale(GCS).Using software SPSS 17.0 to analyze the statistical data of the two groups of patients with intracerebral hemorrhage,and Using spearman correlation to analyze the correlation between admission magnesium level,initial hematoma volume and critical condition.Results A total of 90 cases with intracerebral hemorrhage were collected by inclusion criteria and exclusion criteria.There were 52 males(57.8%)and 38 females(42.2%),with an age range from 60 to 90.The mean age was 68.4±7.0 years.There were 38 cases in the low blood magnesium group,including 20 males(52.6%)and 18 females(47.4%),the mean age was 69.0±7.0 years.The normal blood magnesium group included 52 patients,32 males(61.5%)and 20 females(38.5%),the mean age was 68.0±7.0 years.Comparison of clinical data between the two groups:Low blood magnesium group of patients admitted to hospital random blood glucose in a numerical tendency(7.29 L),the content of fibrinogen degradation products in a numerical(2.50 g/L)were higher than in normal blood magnesium group(6.44L,1.98 g/L),the initial admission median hematoma volume were larger than normal blood magnesium group(20 cm~3vs10 cm~3),The median GCS score at admission were lower than the normal blood magnesium group(12.5vs14.0).The mean hospital length of stay(21.8±8.2days)in the hypomagnesemia group was longer than that in the normal magnesium group(17.7±10.0 days),with statistically significant differences(all P<0.05).Spearman correlation analysis showed that the blood magnesium concentration at admission was negatively correlated with initial hematoma volume(r=-0.528,P=0.001)and positively correlated with admission GCS(r=0.340,P=0.037),and negatively correlated with fibrinogen degradation products(r=-0.324,P=0.002),and negatively correlated with length hospital stay(r=-0.327,P=0.002)..Conclusions Hypomagnesemia has a negative correlation with the initial hematoma volume of cerebral hemorrhage,the severity of hospital admission and the length of hospital stay;Low magnesium levels induced hyperfibrinolysis may be one of the mechanisms leading to early hematoma growth in cerebral hemorrhage.