Detection Of Serum Soluble CD40 Ligand Level In Patients With Subcortical Ischemic Vascular Disease And Its Correlation With Cognitive Function

Objective To investigate the expression level of serum soluble CD40 ligand(sCD40L)in patients with subcortical ischemic vascular disease(SIVD)and its effect on cognitive function.Methods82 patients with SIVD were selected as SIVD group,and 42 healthy subjects were selected as controls.According to the MRI findings of the skull,the white matter lesions(WML)degree(Fazekas score)and lacunar infarction(LI)were evaluated.Serum sCD40 L levels were determined by ELISA.The Mo CA scale was used to evaluate the overall cognitive function.The general data,serum sCD40 L level,brain injury degree,and cognitive function score were compared between SIVD group and control group.Then,the correlation between sCD40 L level and brain damage degree and cognitive function score was analyzed.Results The serum sCD40 L level,Fazekas score and LI number in the SIVD group were significantly higher than those in the control group.The Mo CA score was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).The correlation analysis showed that the sCD40 L level was positive with the Fazekas score(r=0.346,P<0.05)and the LI number(r=0.344,P<0.05),while sCD40 L level was negatively correlated with Mo CA score(r =-0.716,P<0.001).Multiple logistic regression analysis showed total cholesterol(OR=2.427,95% CI: 1.037-5.682),sCD40 L levels(OR=1.248,95% CI: 1.147-1.359)were independent factors of SIVD(P<0.05).Conclusion sCD40 L is involved in the pathogenesis of SIVD,and elevated serum sCD40 L levels may be an independent risk factor for SIVD,and elevated levels of sCD40 L are closely related to the degree of SIVD lesions and cognitive impairment.