| Objective: To investigate the role of hypersensitivity mediated by the combination of IgE and its FcεRI receptor in the pathogenesis of secretory otitis media.Methods: Thirty patients who were hospitalized in our hospital for secretory otitis media from June 2019 to December 2019 were divided into experimental group and control group according to whether they had allergic rhinitis,and 10 patients with allergic rhinitis were tested Group,20 patients without allergic rhinitis were in the control group.The concentrations of IgE and sFcεRI in the middle ear effusion and serum of the patients were measured by ELISA double antibody sandwich method.The measurement indexes in the serum and middle ear effusion of the experimental group and the control group were compared,and analyzed by SPSS statistical software.Results: The concentration of IgE in the peripheral serum of the experimental group was41.32 ± 11.62 ng / mL,and the concentration of IgE in the serum of the control group was 45.71 ± 27.99 ng / mL.There was no statistical difference between the two(P>0.05).The concentration of serum sFcεRI in the experimental group was 60.67 ±9.70 IU / mL,and the concentration in the control group was 66.09 ± 7.36 IU / mL.The difference between the two was not statistically significant(P> 0.05).2.The IgE concentration in the middle ear effusion of the experimental group was 197.38 ±64.25 ng / mL,which was significantly higher than that of the control group,36.07 ±23.57 ng / mL.The difference between the two was statistically significant(P <0.01).The concentration of sFcεRI in the liquid was 20.98 ± 6.51 IU / mL,which was lower than the control group’s 30.49 ± 2.16 IU / mL.The difference between the two was statistically significant(P <0.01).3.The IgE level in the middle ear effusion of the experimental group is higher than the serum IgE level.The difference between the two is statistically significant(P <0.01),while the IgE level in the middle ear effusion of the control group is compared with the serum IgE level.The difference was not statistically significant(P> 0.05).The concentration of sFcεRI in the middle ear effusion of the experimental group and the control group was lower than that in the serum,and the difference between the two was statistically significant(P <0.01).4.The IgE in themiddle ear effusion of the experimental group was negatively correlated with sFcεRI(r=-0.855,P <0.01),and the serum IgE of the experimental group had no significant correlation with sFcεRI(r = 0.244,P = 0.325).In the control group There was no significant correlation between IgE and sFcεRI in auricular fluid(r =-0.06,P = 0.801),and there was no significant correlation between serum IgE and sFcεRI in control group(r =-0.362,P = 0.117).Conclusion: For patients with secretory otitis media,there is no significant difference in IgE and sFcεRI concentrations in peripheral serum,whether or not they are associated with allergic rhinitis,indicating that they did not cause a systemic hypersensitivity reaction,but in secretory otitis media with upper respiratory allergic diseases Elevated IgE levels and decreased sFcεRI were detected in the patient’s middle ear effusion,indicating that the same hypersensitivity mediated by the combination of IgE and its FcεRI receptor as the nasal mucosa occurred in the middle ear mucosa,which confirmed the middle ear The mucous membrane is a continuation of the nasal mucosa.Allergic reactions can occur locally in the middle ear cavity.This reaction participates in the entire process of the development and development of secretory otitis media and is related to the severity of secretory otitis media.The concentration of sFcεRI has a negative correlation with the concentration of IgE,because sFcεRI can combine with free IgE in body fluids to form an sFcεRI-IgE complex,which reduces the binding of IgE to FcεRI on the cell membrane surface,thereby weakening the IgE-mediated hypersensitivity reaction.sFcεRI is an in vivo regulator of IgE-mediated immune response and can antagonize. |
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