Relationship Between Mean Platelet Volume And Acute Cerebral Infarction With Penetrating Artery Disease

Objective:The purpose of this study was to investigate the risk and prognostic significance of mean platelet volume in acute perforating artery cerebral infarction.Methods:Analyzed retrospectively from January 2018 to October 2019 in the fourth affiliated hospital of China medical university neurology acute cerebral infarction with penetrating artery disease of 56 cases of hospitalized patients(experimental group).Patients whose NIHSS score was less than 4 points were classified as mild neurological impairment group,patients whose NIHSS score was 4-15 points were classified as moderate neurological impairment group,and patients whose NIHSS score was > 15 points were classified as severe neurological impairment group.According to the location of the infarction,it was divided into anterior circulation group and posterior circulation group,which were 41 cases and 38 cases.According to the difference value of NIHSS score on the 7th day after admission and at the time of admission(d= NIHSS scores on the 7th day of admission-NIHSS scores at the time of admission),the patients were divided into the improvement group with a d value < 0,and the non-improvement group with a d ≥0.Meanwhile,64 non cerebral infarction patients(control group)were included for control.The measurement data should be tested by independent samples,and the count data should be tested by chi-square test,expressed as n(%);the multivariate analysis was analyzed by Logistic regression.P <0.05 was considered statistically significant.Results: 1.Analyzed the experimental group and control group in clinical general data,the results showed that age,hypertension,diabetes,coronary heart disease(CHD),high-density lipoprotein cholesterol(HDL),smoking history,history of drinking,homocysteine(hcy),mean platelet volume(MPV)and platelet distribution width(PDW)on the inspection of the corresponding P value is less than 0.05,the difference was statistically significant.Multivariate logistic regression analysis was performed,and the differences in age,history of hypertension,CHD,history of alcohol consumption,MPV and PDW were found to be statistically significant.2.In the experimental group,the MPV level of the anterior circulation group(ACA group,MCA group)and the posterior circulation group(PCA group,V-BA group)was found that P>0.05 after two controls,and there was no statistically significance between the difference.3.The difference in the level of MPV between the mild and moderate groups has no significance.4.The improvement group(d < 0)and no improvement group(d≥0)level of MPV comparison,discovered t =-2.553,P = 0.014,can be thought of MPV level differences between the two groups was statistically significant,further MPV levels on admission to hospital(r =-0.636,P = 0.025)and NIHSS score on admission to hospital(r =-0.212,P= 0.042)multiple factors analysis,can think that the higher the level of MPV on admission,the higher the NIHSS score,the worse prognosis.Conclusion:1.Mean platelet volume is an independent risk factor for acute perforating artery cerebral infarction.2.Age,history of hypertension,history of CHD,history of alcohol consumption,MPV and PDW are risk factors for cerebral infarction.3.MPV level may not to be related with the degree of neurological impairment in acute cerebral infarction with penetrating artery disease patients,or to be with the location of cerebral infarction,however is related to the short-term prognosis of PAD-type acute cerebral infarction.It is an important prognostic factor and impact factor,that is,higher MPV level indicates worse prognosis.