| Objective: To observe the visual field defect and the changes of retinal and chor oidal blood flow parameters in the optic disc and macular area during atrophic no n-arterial inflammatory anterior ischemic optic neuropathy(NAION)patients during OCTA(OCT angiography,OCTA)examination.To observe the prognosis of NA ION patients,to find new methods to diagnose NAION in the early clinical stage and new ideas for judging the prognosis.Research methods: A retrospective study was performed.Patients who attended t he Eye Center of the Fourth Affiliated Hospital of China Medical University from November 2018 to December 2019 were selected as the research subjects.A tota l of 30 patients(48 eyes)were selected.Definitely diagnosed as atrophic NAION,complete data,onset time> 3 months and optic nerve atrophy.At the same time,a healthy control group was set up,with no significant difference in age and ge nder,a total of 30 cases(60 eyes).An eye examination was performed on all sel ected candidates to determine the mean visual field defect(MD),the mean root o f lost variance(sLV),and the entire planar retinal blood flow density(wiVD)in the OCTA examination,including radial capillaries(RPC)around the optic disc,a nd optic papillae RPC blood flow density(ppVD),RPC blood flow density near t he nipple(NppVD),RPC blood flow density near the nipple(SppVD),RPC bloo d flow density near the nipple(TppVD),and papilla Results of para-RPC blood f low density(IppVD),superficial capillary plexus(SCP),and deep capillary plexus(DCP).Application software Image J was used to calculate the percentage of vis ual field defect area and the percentage of non-perfusion area of optic disc in N AION patients with atrophy.The differences between the atrophic NAION patient group and the healthy group were compared,and the visual field defect value,t he parameters of the optic disc and macular blood flow changes during the OCT A examination,the visual field defect range,and the area of the non-perfusion ar ea around the optic disc were compared.related analysis.Results: Compared with the normal control group,RPC wiVD,ppVD,NppVD,Ip pVD,TppVD,and SppVD were significantly reduced in the NAION group(t =-13.010,-13.065,-14.329,-9.406,-10.328,-12.761,P <0.001),SCP wiVD was al so significantly reduced(t =-9.606,P <0.05),and DCP wi VD was not significant ly reduced compared to the control group(t =-1.180,P> 0.05).Univariate analys is of variance showed no significant difference in blood flow density(NppVD,Ip pVD,TppVD,SppVD)in different quadrants around the RPC in the NAION grou p(P> 0.05).Correlation analysis showed that BCVA and MD(r =-0.574,P <0.001),sLV(r =-0.635,P <0.001),and the percentage of non-perfused optic disc ar ea in the NAION group(r =-0.569,P <0.01)There was a significant correlation between them(P <0.001).Significant correlations were found between the percen tage of non-perfused area of the optic disc and the percentage of visual field defe ct(r = 0.601,P <0.001)and MD(r = 0.680,P <0.01)in the NAION group(P<0.001).Conclusion: Optic disc and superficial blood flow perfusion in patients with NAI ON in atrophic phase are significantly decreased.Deep perfusion of macular regio n is not significantly reduced,and there is no significant difference in blood perf usion between different quadrants of the optic disk area.The larger the range,the larger the MD value and sLV value of the visual field,and the worse the visual acuity;OCTA examination is helpful to understand the changes of NAION retina l blood perfusion;the combination of OCTA examination and visual field examina tion can better help evaluate the progress and prognosis of NAION. |
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