Magnetic Nanoparticles Enhance The Regulation Of Neuromagnetic Stimulation On Bone Metabolism

Osteoporosis(OP)is a systemic skeletal disease featured by reduced bone mass,degenerated bone microstructure,and increased bone fragility,which is prone to fracture.With the aging of Chinese social population,the incidence of osteoporosis is increasing.Oxytocin(OT)is a nonapeptide neuroendocrine hormone that is synthesized and secreted by the hypothalamic paraventricular nucleus(PVN)cells and released into the blood through the posterior pituitary.It has basic functions such as promoting childbirth,breastfeeding,and preventing postpartum hemorrhage.Notably,the study found that oxytocin is sensitive to bone and has a role in regulating bone metabolism.The hypothalamus secretes oxytocin,which stores oxytocin in the pituitary gland.Under specific conditions,oxytocin is released from the pituitary gland into the blood to play a physiological role.Thus,the hypothalamus closely links the nervous system to the endocrine system.Therefore,based on the regulation of bone metabolism of oxytocin,this paper explores the regulation of neuromagnetic stimulation on bone metabolism.This study develops a new method of neuromagnetic stimulation,based on neuromagnetic stimulation,magnetic nanomaterials are localized and injected into specific brain regions or nuclei of mice,supplemented by external magnetic fields,and finally achieve the secretion of oxytocin to prevention and treatment of osteoporosis.Specific experiments are:(1)Establishing mice model of osteoporosis disease.(2)Stereotactic injection of magnetic nanoparticles in the hypothalamic paraventricular nucleus of mice.(3)The brain is supplemented with a rotating magnetic field for brain stimulation intervention.The specific research contents are as follows:(1)Successful construction of osteoporosis model mice and simulation of applied magnetic field.(2)Magnetic nanoparticles enhance the preventive effect of magnetic stimulation on osteoporosis mice.(3)Magnetic nanoparticles enhance the therapeutic effect of magnetic stimulation on osteoporosis mice.