Analysis Of Risk Factors Affecting Prognosis Of Patients With Pneumocystis Pneumonia After Kidney Transplantation

Objective:Retrospective analysis was made on the related data of long-term use of immunosuppressants and PCP in recipients after renal transplantation,to explore the risk factors affecting the prognosis,strengthen the understanding of clinicians on the disease and the level of diagnosis and treatment,reduce the mortality of the disease,and improve the prognosis of patients.Methods:A retrospective analysis was performed on 77 patients admitted to the department of respiratory and critical care medicine of anhui provincial hospital from2010 to 2019 who were diagnosed with pneumocystis pneumoniae after kidney transplantation after long-term use of immunosuppressants.According to the improved prognosis were divided into group and death group,collected in the two groups of patients age,gender,the number of days after renal transplantation,renal transplantation before dialysis method,clinical manifestation,immunosuppressive therapy,1,3-beta glucan,calcitonin,c-reactive protein and blood sedimentation,T lymphocytes,albumin and creatinine data,carries on the single factor analysis and multiple factor analysis,to explore the risk factors affecting the prognosis.Results :1.In patients with pneumocystis pneumonia after kidney transplantation,there wereno statistically significant differences between the improved group and the dead group in gender,days after kidney transplantation,dialysis methods before kidney transplantation,clinical manifestations,immunosuppressive treatment regimen,1,3-dextran,procalcitonin,c-reactive protein,erythrocyte sedimentation rate,T lymphocytes,etc.2.There were statistically significant differences in age,procalcitonin level,serum creatinine level and serum albumin level between the two groups in patients with pneumocytophore pneumonia after renal transplantation(P<0.05).3.Age,procalcitonin level,plasma creatinine level and serum albumin were included in multivariate Logistic regression analysis,suggesting that serum creatinine level and serum albumin level were independent risk factors for prognosis(P<0.05). Conclusion Based on this data analysis,the prognosis of pneumocystis pneumoniae in recipients after renal transplantation was not correlated with patient gender,postoperative days after renal transplantation,dialysis methods before renal transplantation,clinical manifestations,immunosuppressive treatment regimen,1,3-dextran,c-reactive protein,erythrocyte sedimentation rate,T lymphocytes,etc.Age,procalcitonin,serum creatinine and serum albumin are the high risk factors for the prognosis of pneumocytophore pneumonia after renal transplantation.Serum creatinine and serum albumin levels were independent risk factors for the prognosis of pneumocytidine pneumonia after renal transplantation.In clinical practice,continuous dynamic monitoring of serum creatinine and serum albumin level can be used to determine the prognosis of pneumocytidine pneumonia after renal transplantation,and relevant measures can be taken in advance to improve the mortality.