Analysis Of The Clinical Efficacy Of Quinolones In The Treatment Of Refractory Mycoplasma Pneumonia In Children And Its Effect On Immune Function

Objective:To compare C-reactive protein levels,erythrocyte sedimentation rate(erythrocyte sedimentation rate),lactate dehydrogenase(LDH),D-dimer levels,duration of fever,quinolones and macrolides in children with refractory mycoplasma pneumoniae pneumonia Cough duration,blister sound absorption time,pulmonary imaging absorption time,and changes in T lymphocyte subgroup levels were explored.The clinical efficacy of quinolones and its effect on immune function in children with refractory mycoplasma pneumoniae pneumonia were explored.Methods:1.A study of 164 children with refractory mycoplasmal pneumonia who were hospitalized in the Pediatric Ward and Pediatric Intensive Care Unit(PICU)of Shengjing Hospital(Gliding Hospital District)from December 2015 to August 2019.2.According to the different treatment methods of antibiotics,the children with RMPP who received quinolone antibiotics were classified as observation group,and the RMPP treated with conventional macrolide antibiotics was classified as the control group,82 cases in each group.3.Retrospective analysis was used to collect clinical data of children with RMPP.General information includes:gender,age,time of onset,and critical case score(obtained through assessment of vital signs,blood gas analysis,etc.).Related indicators include:C-reactive protein level,erythrocyte sedimentation,lactate dehydrogenase(LDH),D-dimer,Antipyretic time,fever duration,cough duration,blisters absorption time,lung imaging absorption time,and changes in T lymphocyte subgroup levels.4.Organize and analyze the data using SPSS 21.0.The paired t-test was applied to the measurement data;Count data is applied to theχ~2 test.Results:1.There was no statistical difference between the two groups of children with refractory pneumonia mycoplasma pneumonia(P>0.05),which was comparable;2.There were no statistical differences in C-reactive protein,erythrocyte sedimentation rate,lactate dehydrogenase,D-dimer,Changes in T lymphocyte subsets,modified PIRO score,and antipyretic time before treatment in the two groups P>0.05),but all improved significantly after treatment(P<0.05);3.C-reactive protein,D-dimer,CD3+,CD4+,CD8+,CD4+/CD8+levels,modified PIRO score,and AE-IPF score were significantly better in the observation group than the control group after treatment,with statistical differences(P<0.05));After treatment,the effective rates of the control group and observation group were 65.86%and 86.58%,respectively,and the difference was statistically significant(P<0.05).4.After anti-infective treatment,the antipyretic time,fever duration,cough duration,blisters absorption time,and lung imaging absorption time in the observation group were significantly shorter than those in the control group,which was statistically significant(P<0.05).Conclusion:1.The use of quinolones in the treatment of refractory Pneumoniae pneumonia in children can effectively improve the severity of pneumonia and immune function;2.For larger cyclolipids,quinolones have changes in C-reactive protein,D-dimer levels,and T lymphocyte subsets in children with refractory mycoplasma pneumoniae pneumonia.Significantly improve the effect,and can significantly reduce the antipyretic time,fever duration,cough duration,blisters sound absorption time,lung imaging absorption time.3.Short-term application of macrolides in the treatment of poor results,the use of quinolone in the treatment of children with refractory Mycoplasma pneumoniae pneumonia clinical efficacy is satisfactory.