Clinical Observation Of Tiaogan Daozhi Recipe In The Treatment Of Irritable Bowel Syndrome-Constipation(Liver Qi Stagnation Type)

Objective:The purpose of this study was to observe the clinical efficacy and drug safety of tiaogan daozhi recipe in the treatment of irritable bowel syndrome-constipation(liver qi stagnation type),and provide clinical basis for the treatment of irritable bowel syndrome-constipation(liver qi stagnation type).Methods:The study was conducted by collecting a total of 70 patients with a diagnosis of western medicine and liver qi stagnation type in the gastroenterology clinic of Mianyang Hospital Affiliated to Chengdu University of TCM.They were divided into treatment group(n=35)and control group(n=35)according to the random word table method.The treatment group was treated with Tiaogan Daozhi Recipe,Meanwhile the control group was treated with polyethylene glycol 4000 powder(Fo Sone).The treatment course of both groups was 4 weeks,and follow-up surveys were conducted 4 weeks after the end of the drug withdrawal.The psychological status,clinical comprehensive efficacy and safety of the two groups were observed before and after the treatment.Results:(1)Comparison of clinical comprehensive efficacy:after 4 weeks of treatment,the total effective rate was 94.1% in the treatment group and 78.8% in the control group.The clinical comprehensive efficacy of the treatment group was better than that of the control group(P<0.05).(2)Comparison of total score of TCM symptoms: after 4 weeks of treatment,both groups could effectively improved the total score of TCM symptom(P<0.001),and the treatment group was better than the control group(P<0.001).(3)Comparison of single symptom integral of TCM: after 4 weeks of treatment,both groups could effectively improved the single symptom integral of TCM(P<0.001).Both groups had similar curative effects on defecation frequency and defecation sense(P>0.05),while the treatment group was superior to the control group in terms of abdominal pain or discomfort,stool characteristics,defecation status,chest swelling pain,belching hiccup,mental state and fatigue.(P<0.05).(4)Psychological status: HAMA score and HAMD score were decreased after 4 weeks of treatment in both groups(P<0.001),and the treatment group was better than the control group(P<0.001).(5)Comparison of efficacy in follow-up period: after 4 weeks of drug withdrawal,the total effective rate of the treatment group(88.20%)was better than that of the control group(63.60%).The difference between the two groups was statistically significant(P<0.05).(6)Recurrence: after 4 weeks of withdrawal,there were 2 cases recurred in the treatment group,and the recurrence rate was 6.25%.In the control group,5 cases had recurred,and the recurrence rate was 19.2%.There was no significant difference in recurrence rate between the two groups(P>0.05).(7)There were no adverse reactions in both groups during the treatment.Conclusion:Tiaogan daozhi recipe is effective and safe in the treatment of irritable bowel syndrome-constipation(liver qi stagnation type),which is worthy of further promotion and application in clinic.