A Comparative Study Of The Efficacy Of Indobufen And Warfarin In Secondary Prevention Of Atrial Fibrillation Complicated With Cerebral Infarction

Objective: To investigate the efficacy and safety of indobufen and warfarin in the secondary prevention of atrial fibrillation complicated with cerebral infarction.Methods: A total of 50 patients with atrial fibrillation complicated with cerebral infarction were enrolled in our hospital from October 1st to 2018 th and June 1st,2019.The randomized digital method was divided into warfarin group(n=25 cases)and indobufen group(n=25 cases).Both groups were treated with conventional methods.The warfarin group was given warfarin(the international standard ratio INR was 2.0 to 3.0).The indobufen group was treated with indobufen(200mg,Bid).6 months after treatment.The patients were followed up and the incidence of thrombotic events(cerebral thrombosis,cerebral embolism,peripheral arterial embolism)and the incidence of various bleeding events(including intracranial hemorrhage,urinary tract,gastrointestinal tract,skin mucosa,etc.)and incidence of adverse reactions were recorded.Hemorheology,fibrinogen,coagulation function levels;modified Rank scale,all data in this study were processed using SPSS 25.0 software.Result: 1.The incidence of cerebral thrombosis,cerebral embolism,and peripheral arterial embolism at 6 months after indobufen treatment was 8.00% in the indobufen group and 16.00% in the warfarin group.P>0.05);2.The incidence of intracranial hemorrhage,urinary tract,gastrointestinal tract,respiratory tract and skin mucous membrane bleeding 6 months after treatment was lower in the indobufen group than in the warfarin group(P<0.05);3.There was no statistically significant difference in the incidence of gastrointestinal adverse reactions,liver and kidney abnormalities,dizziness,lethargy,and blood pressure fluctuations during the treatment of indobufen group and warfarin group(P>0.05);4.The high-cut whole blood viscosity,erythrocyte sedimentation rate and fibrinogen of the indobufen group and the warfarin group were lower than those before treatment(P<0.05).The high-cut whole blood viscosity,erythrocyte sedimentation rate and fibrinogen 6 months after treatment in the indobufen group were lower than that of the warfarin group(P<0.05);5.The levels of Prothrombin time(PT),Thrombin time(TT),Thrombin time-activated partial thromboplastin time(APTT)and International standardization ratio(INR)were lower than those before treatment(P<0.05).There was no significant difference in the levels of PT,TT,APTT and INR between the indobufen group and the warfarin group 6 months after treatment(P>0.05);6.The number of cases from 0 to 1 of modified Rank scale in the 6 months after treatment was higher in the indobufen group than that in the warfarin group(P<0.05);the number of cases in the 2-3 points and 4-5 points was lower than that in the warfarin group(P<0.05).Conclusion : For patients with atrial fibrillation complicated with cerebral infarction,compared with warfarin,Indobufen has a tendency to reduce the incidence of ischemic events,But not better than warfarin,Indobufen signifiantly reduces the incidence of bleeding events,and improves coagulation index.