Genetic Biomarkers Of Electroencephalographic Sleep In Depression: A Meta-analysis

Objective: Individuals with major depressive disorder are often associated with sleep abnormalities,and changes in the parameters of sleep electroencephalogram are common.The presence of genetic biomarkers or biological scars that can not be recovered after the treatment is still unclear.Meta-analysis was used to find out whether there were genetic biomarkers and biological scars in MDD patients,and whether there were gender differences in genetic biomarkers and biological scars.Methods: In this study,datebases such as Medline,Psyc INFO,Chinese national knowledge infrastructure(CNKI)and Wan Fang data were searched to retrieve the case-control study of genetic biomarkers and biological scars in MDD published before October 18,2019.Of the 18734 records,48 were eventually included according to the selection criteria.Subgroup analysis or regression analysis was carried out according to factors such as medication,sex,age,and severity of depression.Data analysis was conducted by Stata 15.0 software.Results: The MDD group showed significant abnormalities in several sleep parameters compared with the HC group,but these parameters recovered to varying degrees in the MDR group;SWS% in MDR group was lower than that in MDD group.After divided into three subgroups according to gender(male,female and undivided),it was found that the SWS% in female group was not significantly reduced in MDD vs HC and MDD vs MDR.While the SWS% of the male group and the undivided group was still reduced.The high-risk probands group who had never suffered from depression also showed a shorter severity of SWS% compared to the HC group;Finally,both MDD group and HRP group showed an increase in REM density(REMD)compared with HC group,and there was no significant improvement in MDR.Conclusion: The decrease in SWS% was not only a genetic biomarker,but also a biological scar of the disease in male patients.The rise of REMD is also one of the genetic biomarkers of MDD.