A Meta-analysis Of The Relationship Between Serum Ferritin And Type 2 Diabetes

ObjectiveTo evaluate the relationship between serum ferritin and type 2 diabetes mellitus,a meta-analysis of data was conducted by collecting published literature in the past five years.MethodsPubmed and EMBASE databases were retrieved by computer.All English literatures describing the relationship between iron metabolism and type 2 diabetes mellitus,including prospective cohort study and case-control study,were collected by using retrieval strategies from January 2012 to now.With the limitations of population and sample size,literature was selected according to inclusion and exclusion criteria,relevant research data(OR or RR value)were extracted,and the quality of the included literature was evaluated.Meta-analysis was carried out using 95%confidence interval and other effect measurement indicators.Sensitivity analysis,subgroup analysis and regression analysis were also carried out to evaluate the credibility of the combined effect.Results1.Six English literatures describing the relationship between iron metabolism and type2 diabetes mellitus were included.A total of 36943 subjects were studied,including4390 patients with type 2 diabetes mellitus and 32553 healthy individuals.Five of them described the relationship between ferritin and type 2 diabetes,two described the relationship between transferrin receptor and type 2 diabetes,and one described the relationship between ferritin and type 2 diabetes.2.Using the random effect model and 95% confidence interval,serum ferritin level was significantly correlated with the risk of type 2 diabetes(I-square = 75.3%,p =0.000),the final effect was 0.28(0.15,0.40).3.Subgroup analysis based on the average age of the region,the study population and the number of cases showed that the correlation was more significant among young people(I-squared = 76.1%,p = 0.006)with larger sample size(I-squared = 87.9%,p =0.000)in Asia(I-squared = 84.2%,p = 0.000).Conclusions1.Excessive levels of serum ferritin,one of the indicators of iron metabolism,are one of the main risk factors for type 2 diabetes mellitus.2.The area where the subjects were,the average age of the population and the size of the sample size affected the relationship between ferritin and type 2 diabetes mellitus.3.Monitoring serum ferritin levels may have clinical value in the diagnosis of type 2diabetes mellitus.