| Objective and significanceThis study mainly explored the role of ox-LDL in risk factors in silent cerebral infarction(SBI)and the correlation between different manifestations on craniocerebral magnetic resonance in SBI,and further explored its correlation with cognitive dysfunction,so as to provide early evidence for disease assessment,preventment of symptomatic ischemic cerebrovascular disease,and judgmrt of the severity of cognitive dysfunction.MethodsFrom January 2019 to January 2020,69 SBI patients diagnosed and treated in Shaanxi Provincial People’s Hospital were selected as the observation group,which is called the SBI group.At the same time,67 gender-and age-matched health check-ups who were in the physical examination were selected as the control group.According to the imaging characteristics of cranial MRI and pathogenesis of SBI,it were divided into SBI-1 group(called watershed infarction group,n=19),SBI-2group(called non-lacunar cortical or subcortical infarction group,n=21)and SBI-3group(called lacunar infarction group,n=29).According to the results of the Mini-Mental State Examination Scale(MMSE)score,the group with significant cognitive impairment were divided into non-cognitive dysfunction group,mild cognitive dysfunction group,moderate cognitive dysfunction group and severe cognitive dysfunction group.After admission,the general clinical data of all patients were collected,and the serum ox-LDL concentration was measured by enzyme-linked immunosorbent assay(ELISA).All data were analyzed by SPSS20.0 software.Results1.Comparison of general information between SBI group and control group,age,gender,history of hypertension,history of diabetes,history of heart disease,smoking history,drinking history,years of education,TG,TC,LDL-C,HDL-C,LP-PLA2,HbA1 c and plaque history,the difference between the two groups was not statistically significant(p>0.05);And between the two groups with or without cognitive dysfunction and Hcy were statistically significant(p<0.05).2.The level of serum ox-LDL in the SBI group was significantly higher than that in the control group,the difference was statistically significant(p<0.05).3.Comparison of general information between SBI subgroups,age,gender,history of hypertension,history of diabetes,history of heart disease,smoking history,drinking history,years of education,TG,TC,LDL-C,HDL-C,HCY,LP-PLA2,HbA1 c and plaque history,the difference between the three groups was not statistically significant(p>0.05);In the with or without cognitive dysfunction,the SBI-3 group was significantly higher than the other two groups,and the difference was statistically significant(p<0.05).4.Comparing SBI subgroups,the differences in the the level of serum ox-LDL between the three groups were statistically significant(p<0.05).In pairwise comparison,the serum ox-LDL levels in the SBI-3 group were significantly higher than those in the other two groups(p<0.05).There was no significant difference in ox-LDL between the SBI-2 group and the SBI-1 group(p>0.05).5.Regression analysis between the SBI subgroup and the level of serum ox-LDL showed that ox-LDL was an high risk factor for SBI-3 group.6.The ROC curve was used to analyze the predictive value of the level of serum ox-LDL in the SBI-3 group.When the ox-LDL value was 302.10pg/ml,the results showed that the area under the ROC curve was 0.910(95% CI: 0.844~0.976,p<0.001),and the sensitivity and specificity were 96.6% and 97%.7.Comparison of the level of serum ox-LDL and MMSE score of patients in SBI-3group showed that the ox-LDL with mild to moderate cognitive impairment was higher than those without cognitive impairment,and the difference was statistically significant(p<0.05);the MMSE score of patients with mild to moderate cognitive impairment was lower than that of patients without cognitive impairment,and the difference was statistically significant(p<0.05);the MMSE score of patients with moderate cognitive impairment was lower than that of patients with mild cognitive impairment,and the difference was statistically significant(p<0.05)。8.Correlation analysis between the level of serum ox-LDL and MMSE score inpatients in SBI-3 group with cognitive dysfunction showed that the level of serum ox-LDL was negatively correlated with MMSE score(r=-0.742,p<0.05)。Conclusions1.The level of serum ox-LDL in the SBI group was higher than that in the control group.The level of serum ox-LDL in lacunar cerebral infarction group was higher than that in watershed infarction group and non-lacunar cortex or subcortical infarction group,and was an high risk factor for lacunar cerebral infarction group.2.The level of serum ox-LDL can be a good predictor of lacunar cerebral infarction.3.In the lacunar infarction group,the lower the MMSE score,the higher the level of serum ox-LDL measured,suggesting that the serum ox-LDL concentration is expected to be an index reflecting the severity of cognitive impairment in patients. |
PDF Full Text Request