Association Of Diabetic Nephropathy With The Severity Of Obstructive Sleep Apnea-hypopnea Syndrome In Patients With Type 2 Diabetes Mellitus

PurposeTo analyze the prevalence,characteristics and risk factors of obstructive sleep apnea-hypopnea syndrome(OSAHS)in hospitalized patients with type 2 diabetes mellitus(T2DM).This study aimed to analyze the effect of the severity of obstructive sleep apnea-hypopnea syndrome(OSAHS)on diabetic nephropathy(DN)in patients with type 2 diabetes mellitus.MethodsA total of 322 patients with T2 DM participated in this cross-sectional study.OSAHS was diagnosed according to the apnea-hypopnea index(AHI)and it was categorized as follows: normal,mild,moderate,and severe.Relevant clinical data retrieved from medical charts were cross-analyzed between different groups.The relationship between urinary albumin/creatinine ratio(UACR)and OSAHS parameters,which included AHI,lowest oxygen saturation(L-SaO2),and mean oxygen saturation(M-SaO2),was evaluated by partial correlation analysis.DN stages were classified into a non-DN group,a microalbuminuria group,and a macroalbuminuria group.Multiple factor logistic regression analysis was employed to analyze factors influencing DN.ResultsThe results showed that mild OSAHS,moderate OSAHS,and severe OSAHS patients had a higher Body mass index(BMI),creatinine(CR)level,UACR,and a longer duration of T2DM(P<0.05)than the non-OSAHS group.The prevalence of DN in the non-OSAHS,mild OSAHS,moderate OSAHS,and severe OSAHS groups was 18.4%,19.2%,34.6%,and 49.4%,respectively(P<0.05).Multiple factor logistic regression analysis revealed that systolic blood pressure(SBP)(OR=1.03),AHI(OR=1.02),and duration of T2DM(OR=1.04)were correlated with DN(P<0.05).ConclusionsThis study revealed that OSAHS is highly prevalent in T2 DM and AHI is independently associated with the presence of DN.