A Platform For Research About Neuron Activity In Primary Motor Cortex Of Parkinson’s Disease

Parkinson’s disease(PD)is a common degenerative disease of the motor nervous system.The main lesion is the degeneration and necrosis of dopaminergic neurons in the substantia nigra.This lesion leads to abnormal signal transmission in the cortex-basal ganglia-thalamus loop of the brain,thus causing various motor disorders of PD.Basal ganglia was proved to play an important role in decision-making and motor action organization,and PD patients generally showed defects in motor control and action selection,so we speculated that PD would affect decision-making and motor action organization.Some previous studies on the PD monkey model compared the motor cortex neuron activity differences between the PD monkey and the normal monkey.Those results obtained in different laboratories were significantly different,mainly because the different degree of modeling in PD monkey and the different experimental tasks.The purpose of this study was to establish an experimental platform for the study of neuron activity in primary motor cortex in different stages of PD in rhesus monkeys.First of all,12 healthy human subjects as the experimental subjects were asked to perform an adopted version of a temporal bisection task,and the task-related behavioral data was collected,then 2 rhesus monkeys as experimental subjects were trained to perform the same task,with lateral ventricle infusion of MPP~+method to establish the PD monkey,for researching the task-related changes in action selection and primary motor neuron activity in different stages of PD.The results showed that:1)Different time intervals have influence on action selection.2)The direction of motion has no significant influence on action selection.3)Different music environments have no significant influence on behavioral choice.4)Most of the primary motor cortex neurons have directional selectivity,and they have specific release at the transition time of action selection.The above experiments explored several influencing factors of internal action selection,and the establishment of this platform provided important experimental basis and theoretical basis for subsequent studies on the influence of Parkinson’s disease on motor behavior organization and decision-making process.