Clinical Study On Wen Du Pei Yuan Moxibustion Treatment For Ankylosing Spondylitis Of Kidney Deficiency And Du-meridian Cold Syndrome

Objective:To observe and evaluate the clinical efficacy of Wendu Peiyuan moxibustion in treating AS patients with kidney deficiency and cold syndrome,and provide a reference for the treatment of AS syndrome with kidney deficiency and du-meridian cold syndrome by combining traditional Chinese and western medicine.Methods:70 cases of AS patients(18-50 years old)who were treated in the rheumatology department,acupuncture department clinics and wards of Xiamen Traditional Chinese Medicine Hospital from December 2018 to December 2019 and whose syndrome type was"Deficiency of Kidney Deficiency" were collected.Seventy patients were divided into control group and observation group according to the principle of randomized control,with 35 cases in each group.The control group received oral celecoxib capsules(0.2g,Bid)for continuous treatment for 4 weeks;the observation group added the "Wen Du Pei Yuan" moxibustion method to the observation group for 2 times a week,Continuous treatment for 4 weeks.CRP measurement,TCM syndrome score evaluation,ASAS20-CRP evaluation criteria,ASDAS-CRP calculation were performed before and after treatment for 2 weeks and 2 groups,and the incidence of adverse reactions was recorded.The statistical analysis was used SPSS24.0 statistical software to compare the efficacy of the two groups.Results:1.TCM syndrome scores:The TCM syndrome scores of the two groups were significantly lower than before treatment after 2 and 4 weeks of treatment,the difference was statistically significant(P<0.05);the TCM syndrome scores of the observation group were significantly lower after 4 weeks of treatment In the control group,the difference was statistically significant(P<0.05).2.ASAS20 comparative analysis:After 2 weeks of treatment,the number of cases in the observation group that reached the ASAS20 standard was 14 and the effective rate was 43.75%.The number of cases in the control group that reached the ASAS20 standard was 13 and the effective rate was 39.39%.There was no significant difference in the number of cases(P>0.05).After 4 weeks of treatment in the two groups,the observation group achieved ASAS20 standard for 24 cases with an effective rate of 75.00%;the control group achieved ASAS20 standard for 15 cases with an effective rate of 45.45%,and the difference was statistically significant(P<0.05).3.Comparison of C-reactive protein:After 2 and 4 weeks of treatment,the C-reactive protein of the two groups was lower than before,and the differences were statistically significant(P<0.05);the observation group was compared with the control group after 4 weeks of treatment C-reactive protein was significantly reduced,and the difference was statistically significant(P<0.05).4.PGA,spinal pain,BASFI,and morning stiffness:After 2 and 4 weeks,PGA,spinal pain,BASFI,and morning stiffness were significantly improved in the two groups compared with before treatment,and the difference was statistically significant(P<0.05);Treatment 4 After the treatment,the pain(P<0.05)and BASFI(P<0.05)scores of the observation group were lower than those of the control group,and the difference was statistically significant;but morning stiffness(P>0.05)and PGA(P>0.05)The difference was not statistically significant.5.ASDAS-CRP:The ASDAS-CRP score of the two groups was significantly lower than that before treatment after 2 and 4 weeks of treatment,and the difference was statistically significant(P<0.01);the ASDAS-CRP score of the observation group after 4 weeks of treatment It was significantly lower than the control group,and the difference was statistically significant(P<0.05).6.Adverse reactions:There were statistical differences in adverse reactions between the two groups after comparison(P<0.05).Conclusions:Wen Du Pei Yuan moxibustion treatment can significantly improve the symptoms of patients withkidney deficiency and du-meridian cold syndrome,increase the ASAS20 compliance rate,reduce the inflammation index,disease activity and the incidence of adverse reactions caused by taking celecoxib,and improve the overall efficacy.It is expected to improve the quality of life and psychological state of patients,and achieve the advantage of"increasing efficacy and reducing toxicity" in the combination of traditional Chinese and Western medicine.