Disease Spectrum And Prognosis Of Rare Lung Malignancies

Objective: To analyze the disease spectrum and prognosis of each pathological subtype of rare lung malignancies,so as to help to develop the clinical strategies of this type of tumor.Methods: We obtained the data of rare lung malignancies diagnosed from 2004 to 2015 in the SEER database and analyze the composition and incidence trend of each subtype.Kaplan-Meier method was used to calculate the 1-,3-,and 5-year survival rates and draw the survival curve.Results: A total of 13428 patients were included,including large cell carcinoma,adenosquamous carcinoma,sarcomatoid carcinomas,salivary gland-type tumor,lymphoepithelial carcinoma,mesenchymal tumors,tumors of ectopic origin,accounting for 49.00%,32.31%,10.23%,2.49%,0.28%,5.38%,and 5.38%,respectively.And their composition ratios in all lung malignancies in the same period were 1.72%,1.13%,0.36%,0.09%,0.01%,0.19%,and 0.01%,respectively.The Composition ratio of large cell carcinoma decreased year by year,while adenosquamous carcinoma increased slowly.The 5-year overall survival rate of all patients with rare lung malignancy was 16.86%,the median survival time was 8 months.The survival differences of each pathological subtype were statistically significant(P <0.05).Conclusion: Adenosquamous carcinoma of the lung has become the first rare malignant tumor in the sequence of incidence.Rare malignant tumors in the lung have poor overall prognosis due to the low rate of driving gene mutation and more likely to have rare mutation types.