Expression And Significance Of YAP、TAZ And Survivin In Cervical Cancer

Objective:To detect the expression of YAP、TAZ and Survivin in the tissue of cervical cancer and normal cervical.To analyze the expression of YAP、TAZ and Survivin in cervical cancer tissues.To analyze the relationship between YAP、TAZ、Survivinin and the clinical characteristics of patients with cervical cancer.To analyze the correlation of YAP、TAZ and Survivin.To discuss the molecular mechanism and influencing factors of Hippo signaling pathway and its value in the treatment and prognosis of cervical cancer.Methods:The expression of YAP、TAZ and Survivin in 64 cases of cervical cancer and 32 cases of normal cervical tissues was detected by using immunohistochemistry staining method.Rank sum test analysis methods were used to analyze the expression of three kinds of protein in cervical cancer tissues.Chi-square test analysis methods were used to analyze the relationship between three kinds of protein and the clinical characteristics.Spearman rank correlation analysis methods were used to analyze the correlation among three kinds of protein.Results:1.The positive expression rate of YAP in cervical cancer tissues was 71.88%,while the positive expression rate in normal cervical tissues was 25.00%.The difference was statistically significant(Z=-4.227,P<0.05).2.The positive expression rate of TAZ in cervical cancer tissues was 68.75%,while the positive expression rate in normal cervical tissues was 12.50%.The difference was statistically significant(Z=-4.941,P<0.05).3.The positive expression rate of Survivin in cervical cancer tissues was62.50%,while the positive expression rate in normal cervical tissues was18.75%.The difference was statistically significant(Z=-3.762,P<0.05).4.The expression of YAP was significantly correlated with the depth ofinfiltration of cervical cancer tissues、lymph node metastasis and FIGO stage(P<0.05),and had nothing to do with the degree of differentiation of cervical cancer tissues and the age of cervical cancer patients(P>0.05).5.The expression of TAZ was significantly correlated with the degree ofdifferentiation and the depth of infiltration of cervical cancer tissues、lymphnode metastasis and FIGO stage(P<0.05),and had nothing to do with the theage of cervical cancer patients(P>0.05).6.The expression of Survivin was significantly correlated with the depth ofinfiltration of cervical cancer tissues、lymph node metastasis and FIGOstage(P<0.05),and had nothing to do with the degree of differentiation ofcervical cancer tissues and the age of cervical cancer patients(P>0.05).7.In cervical cancer tissues,there was a significant positive correlation betweenYAP and TAZ(r_s=0.619,P<0.005),and no significant correlation betweenYAP and Survivin(r_s=0.232,P>0.005),and no significant correlationbetween TAZ and Survivin(r_s=0.281,P>0.005).Conclusion:1.The expressions of YAP,TAZ and Survivin in cervical cancer tissues arehigher than those in normal cervical tissues,which are significantlycorrelated with the infiltration depth of cervical cancer tissues,lymph nodemetastasis and FIGO stage.This three kinds of protein may play a role inpromoting the occurrence,development and invasion of cervical cancer,andmay make greater effects to evaluate the prognosis of cervical cancerpatients.2.The expression of YAP and TAZ was positively correlated in cervical cancertissues,which verified that both of them were the coordination of homologoushelper transcription factors in Hippo signaling pathway,jointly promoting theoccurrence and development of cervical cancer.3.The expression of YAP and TAZ is not significantly correlated with theexpression of Survivin in cervical cancer tissues.They may be regulated byregulatory factors in the upstream and downstream complex protein networkin the Hippo signaling pathway.4.The expression of YAP,TAZ and Survivin in cervical cancer tissues and themolecular mechanism of the occurrence and development in cervical cancerprovide a basis for finding potential drug targets for the treatment of cervicalcancer.