Clinical Phenotypic Analysis Of Patients With Early Onset And Late Onset Psoriasis

Background There are obvious differences in the clinical features and genetic characteristics of early-onset psoriasis and late-onset psoriasis.There are currently two types of divisions.Early-onset and late-onset psoriasis are classified according to the age of 30 or 40 years old.However,there are controversies about certain clinical phenotypes of both types.Objective To explore the differences in phenotypes such as gender,BMI,KP,family history,nail damage,severity,and comorbidities in patients within early-onset and late-onset psoriasis,and discuss which situation is more likely to show clinical differences between the two types.Methods Questionnaires were used to investigate the psoriasis patients attending the dermatology clinic of our hospital.The relevant data in the questionnaire were sorted into Excel,and the data were analyzed by SPSS software.The statistical method included the χ2 test,and the test level was bilateral α=0.05,P<0.05 was considered statistically significant.Results 1、 In terms of gender,BMI,KP,family history,nail damage and type of disease,the statistical analysis results of the two divisions are consistent,that is,more male patients in the late-onset group,and more positive in the family history of the earlyonset group.There was no difference in the degree of BMI,the incidence of KP,the prevalence of nail damage and the type of disease.2、 In terms of severity,both groups were mostly mild to moderate patients,but the early-onset group was more mild than the late-onset group.Compared with the early-onset group,the late-onset group had more severe patients.If the age of onset is bounded by 40 years of age,there is no significant difference in the severity of the patients between the groups.3、 In terms of comorbidities,regardless of the age of onset,30 years old or 40 years old,the prevalence of hypertension and coronary heart disease in the early-onset group was significantly lower than that in the late-onset group.There was no significant difference between the two types in terms of diabetes and high blood lipid prevalence.The prevalence of diabetes in the late-onset group was significantly higher than that in the early-onset group.There was no difference between the two groups in terms of anxiety,depression,malignancy,vitiligo,gout,and rigidity.4、 About the onset season,the early onset group had the most incidence in winter,followed by summer.Patients in the late-onset group were mainly affected by spring,followed by autumn and winter.In addition,the memory forgetting rate of the lateonset group was higher than that of the early-onset group.5、 About the aggravating season,the aggravating season between the two groups is: exacerbated in winter and better in summer.6、 In terms of the skin lesion,there was no significant difference in the location of the two groups of patients.On the whole,the affected parts of the skin lesions are the lower limbs,the upper limbs,the trunk,and the face.About 50% of the patients will suffer from skin lesions of the whole body.Conclusions The early-onset group and the late-onset group,which were divided by 30 years old,had significant differences in the sex,family history,severity,and associated diseases such as hypertension and coronary heart disease.There was a significant difference in the associated disease-diabetes between the two groups divided by 40 years old.Patients in the early-onset group had the most incidence in winter,followed by summer.Patients in the late-onset group were mainly affected by spring,followed by autumn and winter.The aggravating season between the two groups is: exacerbated in winter and better in summer.