Impact Of Body Mass Index In Various Responders Undergoing In Vitro Fertilization

Objective:To explore the impact of body mass index(BMI)in the process and outcomes in various responders undergoing in vitro fertilization.Methods:The clinical data of 1712 patients with IVF assisted pregnancy and fresh cycle transplantation in the Department of Reproductive Genetics retrospectively,the first hospital of Shanxi Medical University from 2014 to 2018 were collected.Firstly,all the patients were divided into four subgroups:low response group,normal response group and high response group.Then the patients in each group were divided into four subgroups:low body weight recombination(BMI<18.5 kg/m~2),normal body weight group(18.5~24kg/m~2),super recombination(24~28 kg/m~2)and obesity group(BMI≥28 kg/m~2),each group was compared pregnancy outcome.Finally,all patients with PCOS were compared again according to BMI.Results:1.In each ovarian response group,the lowest initial dose,the shortest duration and the lowest total dose of low body recombinant Gn were found;in obesity group,the highest initial dose,the longest duration and the highest total dose of Gn were found.2.In the normal ovarian response group,the implantation rate was the highest in the normal weight group,followed by the overweight and obesity group,and the lowest in the low body weight group(P<0.05).3.In the high response group of ovarythe number of eggs obtained in normal weight group was the most,while that in super recombination and obesity group was the least,the number of cleavage was the most in normal weight group(P<0.05),but the cancellation rate of cycle in obesity group was significantly lower than that in low recombination,normal weight group and super recombination(P<0.05).4.In PCOS group,the number of available embryos and the rate of embryo implantation in obese group were lower than those in normal weight group(P<0.05),and the number of newborns with birth weight≥4 000 g in obese group was more(P<0.05).5.There was also no significant difference in fertilization rate,clinical pregnancy rate,live birth rate,abortion rate and cesarean section rate among the groups(P>0.05).Conclusion:The duration of female infertility prolonged with BMI increased.In the process of IVF assisted pregnancy,BMI not only affects the effect of ovulation induction(i.e.the initial dose,use time and total dose of Gn,the number of oocytes obtained),but also affects the number of cleavage,available embryos,embryo implantation rate,cycle cancellation rate and newborn birth weight.PCOS may aggravate these negative effects.Low or high BMI may affect the outcome of pregnancy.