The Prognostic Value Of Absolute Lymphocyte Count In Patients With Newly Diagnosed Adult Primary Immune Thrombocytopenia

Objective:To explore the influence of absolute lymphocyte count(ALC)on the prognosis of newly diagnosed primary immune thrombocytopenia(ITP)in adults,in order to provide more evidence for the treatment of ITP.Methods:The clinical and laboratory examination results of 152 newly diagnosed adult ITP patients were retrospectively analyzed.The influence of ALC on the prognosis of the disease was discussed,and clinical features and prognostic factors of adult ITP were analysed.Results:Among 152 newly diagnosed adult ITP patients,62 were male and 90were female,and the ratio of male to female was 0.69:1.00,with an median age was 50.5(27.0~63.0)years old.With a median follow-up of 9.75(3.88~25.00)months,there were 24 patients(15.78%)who finally relapsed.The receiver operating characteristics(ROC)curve of peripheral blood ALC was obtained with the disease recurrence as the endpoint.The cut-off point value of ALC was 1.070�10~9/L,the area under the curve(AUC)was 0.604(95%CI:0.491~0.717).Taking 1.070�10~9/L as the boundary,the group was divided into high ALC group and low ALC group.The comparison of clinical features between the two groups showed that patients with hypertension in the high ALC group was significantly higher than that in the low ALC group(P=0.006,P<0.05),and there were no statistically significant differences in other clinical features between two groups(P>0.05).Single factor analysis and multi factor Logistic regression analysis on the clinical characteristics of disease recurrence showed that ALC>1.070�10~9/L was the independent risk factor of ITP recurrence in newly diagnosed adults(P=0.004,P<0.05).Conclusion:For newly diagnosed adult ITP patients,a higher lymphocyte count has a certain predictive effect on disease recurrence,which need to be taken into account.