Effect Of Sarcopenia On Pulmonary Function,Blood Gas Analysis Index Of COPD Patients And Correlation Analysis

The morbidity and mortality of chronic obstructive pulmonary disease(COPD)are increasing year by year,and it is one of the diseases with the highest mortality rate in the world.Sarcopenia,as a kind of disease,is getting more and more attention,which seriously affects the quality and function of muscles.It is found that the proportion of patients with chronic obstructive pulmonary disease(COPD)with sarcopenia is not small,and there is a growing trend.At present,there are few studies on chronic obstructive pulmonary disease complicated with sarcopenia.At present,there are few studies on chronic obstructive pulmonary disease(COPD)with sarcopenia.This study focuses on the relationship between sarcopenia and pulmonary function,ventilation function,blood gas analysis index and related risk factors in patients with COPD.Objective:To observe the effect of sarcopenia on the changes of pulmonary function index and blood gas analysis index of chronic obstructive pulmonary disease(COPD),and the risk factors of COPD with sarcopenia.Method:From February 2019 to January 2020,52 patients(29 males and 23 females)with chronic obstructive pulmonary disease(COPD)were admitted to the department of respiratory and critical care medicine,Bethune first hospital,jilin university.Their ages ranged from 37 to 80 years old,with an average age of 61.52 ±10.23 years old.Among them,whether combined with sarcopenia was divided into sarcopenia group(19 cases)and non-sarcopenia group(33 cases).Respectively after admission to collect the basic information of the two groups of patients: age,gender,history of smoking,drinking,by asking assess m MRC score,measure the height,weight,body fat ingredients(including: skeletal mass(SM),appendicular skeletal mass(AM),fat mass(FM),fat free mass(FFM)),pulmonary ventilation function testing(including:Forced vital capacity(FVC),forced expiratory volume in the first seconds of expected value percentage(FEV1/pred %),the first second forced expiratory volume ratio of forced vital capacity(FEV1 / FVC),peak expiratory flow(PEF),maximum mid expiratory flow take up of the expected(MMEF75/25 pred %),blood gas analysis test(Pa O2 higher partial pressure,artery CO2 partial pressure Pa CO2),serology indexes(including: C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),white blood cell count(WBC),albumin(ALB)).Result:1.The age of patients in the sarcopenia group was higher than that in the non-sarcopenia group,and the difference was statistically significant(P < 0.05).In terms of height and weight,patients in the sarcopenia group were lower than those in the non-sarcopenia group,with statistically significant differences(P < 0.05).The number of smoking patients in the sarcopenia group was higher than that in the non-sarcopenia group,and the difference was statistically significant(P <0.05).There was no statistically significant difference between the two groups in gender,BMI,history of alcohol consumption,and combination of hypertension and diabetes(P > 0.05).2.SM,AM,FFM and trunk muscle mass of patients in the sarcopenia group were lower than those in the non-sarcopenia group,with statistically significant differences(P < 0.05).The 6-minute walking distance,speed and dominant hand grip strength of patients in the sarcopenia group were significantly lower than those in the non-sarcopenia group,with statistically significant differences(P < 0.05).Although SMI and FFMI in the sarcopenia group were lower than those in the non-sarcopenia group,the difference was not statistically significant(P > 0.05).FM and FMI in the sarcopenia group were higher than that in the non-sarcopenia group,with no statistically significant difference(P > 0.05).3.The difference in CRP,ESR,WBC and ALB between the two groups was not statistically significant(P > 0.05).4.FVC of pulmonary function index of patients in the non-sarcopenia group was higher than that in the sarcopenia group(P < 0.05).There was no statistically significant difference in FVC/pred%,FEV1,MVand FEV1/pred%between the two groups.There was no statistically significant difference in FEV1/FVC,PEF/pred%,MMEF75/25 /pred% and their improvement rates before and after the application of bronchodilator(P > 0.05).5.When comparing the two groups of patients with blood gas analysis,it was found that the arterial CO2 in the sarcopenia group was higher than that in the non-sarcopenia group,and the difference was statistically significant(P<0.001).The arterial oxygen partial pressure index of patients in the sarcopenia group was lower than that in the non-sarcopenia group,and the difference was not statistically significant(P > 0.05).6.Logistic regression analysis was used to investigate the risk factors of COPD patients with sarcopenia.There were 19 patients in the sarcopenia group and33 patients in the non-sarcopenia group.Pa CO2 and m MRC scores were independent risk factors.7.The 6-minute walking distance and speed in the sarcopenia group were negatively correlated with the arterial Pa CO2 and m MRC scores in the blood gas analysis indexes,with statistically significant differences(P < 0.05).Conclusion:1、Patients with chronic obstructive pulmonary disease(COPD)with sarcopenia were older and more likely to have lower height and weight indicators2、In patients with chronic obstructive pulmonary disease(COPD)with sarcopenia,there are changes in body composition,that is,the muscle mass of each part of the body is significantly reduced,and there are also decreases in the activity ability of both lower limbs and both upper limbs that show muscle function.3、Patients with COPD with sarcopenia are more likely to develop carbon dioxide retention and have more difficulty breathing.4、Sarcopenia can lead to the reduction of forced pulmonary capacity in the lung function of chronic obstructive pulmonary disease.5、Pa CO2 and m MRC scores are risk factors for COPD with sarcopenia.