Intervention Analysis Of One-stop AIDS Service In Zhuhai City On Antiviral Treatment Of HIV/AIDS Patients

Objective:By observing and analyzing the intervention of one-stop AIDS service in Zhuhai on antiviral treatment and follow-up of HIV/AIDS patients,it provides theoretical basis for further improving AIDS prevention and control and treatment strategy.Methods:Methods Retrospective study was conducted to collect the cases that met the inclusion and exclusion criteria before and after one-stop AIDS service in Zh-uhai.A total of 385 cases were collected and divided into control group and observation group,of which 141 patients were HIV/AIDS before one-stop service（Janua-ry 1,2013 to December 31,2014）and 244 patients were HIV/AIDS after one-stop service in the observation group（January 1,2016 to December 31,2017）.To observe and analyze the sociodemographic characteristics,baseline CD₄⁺T lymphocyte count,whether they had opportunistic infection before antiviral treatment,antiviral ti-me（A time interval between the HIV confirmation test and the beginning of the antiviral test）,and ART timely rate（Antiviral treatment time≤30 days）,and proportion of drug withdrawal in the first year of antiviral therapy,examination compliance and virological inhibition rate,and CD₄⁺T lymphocyte count in the first year of antiviral therapy.Results:1.Social demographic characteristics:The proportion of patients with same-sex transmission through men was higher in observation group（71.3%）than in control group（56.0%）,and the difference was significant（P<0.05）.Gender,age of illness,marital status,education level,current addresswere not significantly different between the two groups（P>0.05）.3.Baseline CD₄⁺T lymphocyte counts of the control group and the observation group were not significantly different（P>0.05）.The proportion of patients with opp-ortunistic infection before antiviral treatment in the observation group（9.4%）was lower than that in the control group（25.5%）,there is a significant difference（P<0.05）.3.The median interval between confirmation of positive and initiation of antiviral therapy were significantly shortened from 19 days in the control group to 15 d-ays in the observation group（Z=-2.890,P<0.05）.ART timely rate in the observation group（79.9%）was higher than that in the control group（68.1%）,and the difference was significant（P<0.05）.4.Treatment follow-up and examination compliance:The proportion of patients who stopped drugs after 1 year of antiviral therapy was higher in the observation group（9.4%）than in the control group（3.5%）,and the difference was significant（P<0.05）.The compliance of blood biochemical examination,CD₄⁺T lymphocyte count examination and HIV RNA examination of AIDS patients treated with antiviral therapy were higher in the observation group（89.7%、89.6%、84.4%）than in the control group（85.0%、85.4%、74.2%）,all have significant differences（P<0.05）.5.In the first year of antiviral therapy,the proportion of virological inhibition and there was no significant difference between the observation group（88.4%）and t-he control group（87.8%）（P>0.05）.Baseline CD₄⁺T lymphocyte count（（?）±s）,antivir-al treatment for 1 year CD₄⁺T lymphocyte count（（?）±s）,anti-viral treatment for 1year increased CD₄⁺T lymphocyte count（（?）±s）,there was no significant difference between the observation group and the control group（P>0.05）.Conclusion:1.The one-stop service mode of AIDS significantly shortens the time interval between HIV antibody confirmation test and antiviral treatment,improves the timely rate of ART and promotes the early treatment of HIV/AIDS patients.2.AIDS one-stop service model helps to improve the examination compliance of HIV/AIDS patients.3.AIDS one-stop service has expanded the range of HIV/AIDS patients with antiviral treatment,and it is particularly important to strengthen medication compliance education.