| Background and Objectives:Type 2 diabetes is a group of clinical syndromes that are mostly caused by insulin resistance,leading to a relative lack of insulin,with macroscopic,microvascular,and neuropathy throughout the body.The clinical pathology of diabetes shows that it is mainly caused by endothelial dysfunction,increased inflammatory plaque infiltration,overexpression of adhesion molecules,and the adverse effects of circulating fatty acids and advanced glycation end products,leading to various pathological changes,leading to arterial sclerosis Increased and hypercoagulability promotes the occurrence of cardiovascular and cerebrovascular diseases,leading to a decline in quality of life and shortened life expectancy.Therefore,in addition to proper glycemic control,multi-factor intervention for different risk factors(such as hypertension,dyslipidemia,and carotid atherosclerosis)is essential for the treatment of diabetes.Cardiovascular prognosis tests have confirmed that glucagon-like peptide-1 receptor agonists can benefit the cardiovascular and cerebrovascular vessels by treating carotid atherosclerosis.This article discusses patients with type 2 diabetes and carotid atherosclerosis,analyzes the carotid intima thickness,plaque area,blood glucose level,blood lipid content and other indicators before and after using GLP-1Ra or conventional treatment,and compares anti-atherosclerosis with different treatment options.Like hardening effect.Methods:A retrospective study of 64 patients who were diagnosed with type 2 diabetes and carotid atherosclerosis in our hospital from November 2017 to September 2019 was divided into the GLP-1 Ra treatment group(n = 32)and conventional treatment group(n = 32).In addition to the above two different hypoglycemic regimens,statins and other drugs are also added to the baseline regimen.Information before and after treatment was collected retrospectively,including detailed medical history,medication status,and observation indicators: carotid medial intimal thickness,plaque area,and other changes in glucose and lipid metabolism.The medical records are recorded by professionals who guide sports diet,medication use,blood glucose monitoring,and adverse reactions.Statistical software such as SPSS was used to compare and analyze the above two groups of experimental data,respectively,to observe the anti-atherosclerotic efficacy of the two treatment schemes in patients with type 2 diabetes.Results:1.The results of independent sample T test and chi square test showed that the age,sex ratio,diabetes duration,weight,BMI,blood pressure,glucose and lipid metabolism index,carotid intima-media thickness,and plaque area of the two groups of data were measured at baseline before treatment.Other basic medical history and laboratory data were not statistically different(p> 0.05).Compared with the conventional group,the IMT,plaque area,weight,BMI,systolic blood pressure,and low-density lipoprotein concentration in the GLP-1Ra group were more significantly improved after treatment than those in the conventional group(p <0.05).2.Paired sample T test results show: after treatment,cIMT,glycated hemoglobin,FPG,FIN,HOMA-IR,triglyceride,low density lipoprotein,high density lipoprotein,total cholesterol,etc.in the GLP-1Ra group and the conventional group All were improved(p <0.05);the changes in plaque area did not reach statistically significant improvement(p> 0.05).3.The results of Pearson correlation analysis showed that the improvement of cIMT of patients in the GLP-1Ra treatment group was related to the improvement of steady-state insulin resistance index.The data distribution conformed to the normal distribution(p> 0.05).No abnormal values were found.Pearson correlation analysis: There is a high correlation between the two,r = 0.723,p <0.01.Conclusion:1.Compared with the conventional treatment group,the GLP-1Ra group can reduce the carotid intima-media thickness,but it cannot significantly reduce the plaque area,and can improve the carotid atherosclerosis to a certain extent;2.Compared with the conventional group,the GLP-1Ra group has the same effect of reducing blood sugar,and has more obvious advantages in weight loss,lipid reduction and systolic blood pressure;3.GLP-1Ra may improve carotid atherosclerosis in patients with type 2 diabetes by improving their insulin resistance. |
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