Study On The Relationship Between The Lateral Development Tumor Of Large Intestine And Its Influencing Factors,Constitution Of Traditional Chinese Medicine

Objective To study the clinical characteristics of lateral spreading tumor(LST)of large intestine,to study the correlation between LST and influencing factors,TCM Constitution,to explore the law of LST occurrence and development,and to provide basic theoretical research for the prevention and screening of colorectal cancer.Methods In this study,case-control study method was used;patients were collected from comprehensive top three hospitals such as Shanxi Provincial Hospital of traditional Chinese medicine,Shanxi grand hospital,Shanxi Provincial People’s Hospital,affiliated hospitals of Changzhi City Institute of traditional Chinese medicine,Wanrong County Hospital of traditional Chinese medicine,Jinzhong City Hospital of traditional Chinese Medicine and other county and municipal hospitals,from January 2017 to January 2020 for electronic colonoscopy examination,to collect and clarify pathological organization 158 cases of LST patients and other non LST patients were collected by questionnaire.The basic information of patients and the constitution type of traditional Chinese medicine were recorded in Excel table to establish database.Spss26.0 statistical software was used for chi square test,logistic regression and other statistical analysis methods to explore the clinical characteristics of LST and its correlation with influencing factors and constitution of traditional Chinese medicine.Results1.The distribution of LST: in patients with LST,there is only one LST lesion;the growth site is mainly rectum;the mixed nodule is the main type in granular type,and the flat protuberance is the main type in non granular type;the low-grade intraepithelial neoplasia is the main type in histopathology;the correlation study found that:morphological classification and growth site of lesions,histological classification,and diameter of lesions,There is a correlation between the constitution of traditional Chinese medicine and gender,but all of them are weak.There is no evidence for the correlation between the other relationships.2.Case control study data comparison: case group,control group were 158 patients.There were 85 males and 73 females in the case group,and 80 males and 78 females in the control group.After ?2 tests,P > 0.05,there was no significant difference between the two groups.The average age of the two groups was(64.60 ± 10.193)years old and(64.46 ±10.187)years old respectively.By t-test,P > 0.05,there was no significant difference between the two groups.3.The correlation between LST and influencing factors: the logistic regression analysis showed that the occupational nature and taste were all P < 0.05,the difference was statistically significant,which was the influencing factors of LST;the six factors of diabetes,hyperlipidemia,smoking,hypertension,diet matching,drinking were p > 0.05,which could not be proved to be related to the occurrence of LST.According to the dumb variables(P < 0.05),mental strength was the main factor,physical strength was the main factor,and the difference between the pungent taste and the reference standard was statistically significant.Brain power(or = 3.074)and physical strength(or = 3.775)were the strong risk factors for LST,and appetite for spicy food(or = 0.175)was the protective factor.4.The correlation between LST and TCM Constitution: by logistic regression analysis of 9 TCM constitutions and whether LST is suffered,it is found that Yang deficiency(or =5.324)is a strong risk factor for LST;Qi deficiency(or = 0.226),yin deficiency(or = 0.081)and blood stasis(or = 0.161)are protective factors for LST.Conclusion1.Among the patients in the digestive endoscopy center,the large intestine LST patients,60-69 years old,had the largest number;most of them had only one LST lesion;the growth site was mainly rectum;most of the granular type was nodular mixed type,most of the non granular type was flat protuberant type;most of the pathological histology was low-grade intraepithelial neoplasia.2.Strong risk factors of LST: work "mainly mental" or "mainly physical";protective factors: spicy taste.3.Yang deficiency constitution is the strong dangerous constitution of LST,Qi deficiency constitution,yin deficiency constitution and blood stasis constitution are the protective constitution.4.In the future screening process of colonoscopy,the rectal segment should be carefully examined;the patients aged 60-69 or with risk factors and physical fitness should be focused on,and the longest interval of reexamination should be reduced to less than 3years;once LST lesions are found,they should be removed in the near future to prevent cancer.