Association Between Serum Vitamin D Level And Primary Biliary Cholangitis: A Meta-analysis

Background and Objective:Primary biliary cholangitis(PBC),formerly known as "primary biliary cirrhosis(PBC)",is a common autoimmune liver disease in clinic,which is prone to cause misdiagnosis and missed diagnosis,and lacks specific methods in treatment.Studies have shown that there is a clinical correlation between serum vitamin D levels and PBC,but the results are not consistent.Therefore,We performed a meta-analysis to evaluate the serum vitamin D levels in patients with PBC and controls.To provide new references for the diagnosis and treatment of PBC.Methods:Data were extracted from PubMed,Web of science,Embase,Cochrane Library,CNKI,WanFang Data and VIP database from inception to December 2019.Search for studies on the association between PBC and serum vitamin D level,and formulate strict inclusion and exclusion criteria to screen the literature.the New Ottawa Scale(NOS)score of the included original study should be ≥ 5,and valid data is extracted from it to draw tables.In addition,our Meta-analysis was conducted by RevMan5.3 software.Results:There were 10 trials included in the present analyses.The results showed that:(1)The levels of serum 25(OH)D in PBC patients were significantly reduced compared with healthy controls,and the difference was statistically significant(P < 0.01).(2)The levels of 25(OH)D in the PBC group was similar to that in other etiological cirrhosis groups,but there was no significant difference between the two groups(P>0.05).(3)The level of serum 25(OH)D in PBC group was significantly lower than that in hepatitis B group(P < 0.05).Conclusions:Despite the high heterogeneity among studies,limited data analysis showed that :(1)The levels of 25(OH)D in PBC was significantly lower than those in control group.Vitamin D deficiency is associated with PBC.Combined with previous studies,it is considered that there is a causal relationship between VitD deficiency and the incidence of PBC.Clinically,the measurement of serum 25(OH)D level can be used as an auxiliary diagnostic indicator of PBC,and the addition of VitD may provide new ideas for prevention and treatment of PBC.(2)It can not be considered that there is a difference in serum VitD levels between PBC group and other etiological cirrhosis groups.(3)It is considered that the level of serum VitD in PBC group is significantly lower than that in hepatitis B.